Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma

Ekaterina Y. Lukianova-Hleb; Xiaoyang Ren; Rupa R. Sawant; Ann M. Gillenwater; Michael Kupferman; Ehab Y. Hanna; Joseph A. Zasadzinski; Xiangwei Wu; Vladimir P. Torchilin; Dmitri O. Lapotko

doi:10.1117/12.2038277

Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma

Ekaterina Y. Lukianova-Hleb, Xiaoyang Ren, Rupa R. Sawant, Ann M. Gillenwater, Michael Kupferman, Ehab Y. Hanna, Joseph A. Zasadzinski, Xiangwei Wu, Vladimir P. Torchilin, Dmitri O. Lapotko

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Chemoradiation-resistant cancer cells and unresectable micro-tumors limit treatment efficacy and lead to high nonspecific toxicity or recurrence in head and neck cancers. We show the cancer cell-specific, on-demand enhancement of the chemo- and chemoradiation therapy with mechanical intracellular impact of plasmonic nanobubbles, a laser pulseinduced explosive nano-event, not a particle. We report cellular mechanisms of cancer cell-specific detection and enhancement of the entry drug and X-ray dose and validate these mechanisms in vitro and in vivo for head and neck squamous cell carcinoma. Plasmonic nanobubble technology showed more than 10-fold enhancement of the therapeutic efficacy compared to standard chemoradiation in murine models of primary, microscopic residual and recurrent diseases. At the same time our technology efficiently spared adjacent normal tissues due to the reduction of the effective therapeutic doses of drug by 30-40 fold, X-rays by 15-fold and the treatment time to a single procedure. The developed plasmonic nanobubble technology transforms a standard macro-therapy into a cell-level on-demand theranostic treatment for primary, adjuvant and adjunct applications.

Original language	English (US)
Title of host publication	Photonic Therapeutics and Diagnostics X
Publisher	SPIE
ISBN (Print)	9780819498397
DOIs	https://doi.org/10.1117/12.2038277
State	Published - 2014
Event	Photonic Therapeutics and Diagnostics X - San Francisco, CA, United States Duration: Feb 1 2014 → Feb 2 2014

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8926
ISSN (Print)	1605-7422

Other

Other	Photonic Therapeutics and Diagnostics X
Country/Territory	United States
City	San Francisco, CA
Period	2/1/14 → 2/2/14

Keywords

Drug carrier
Gold nanoparticle
Laser
Plasmonic nanobubble
X-rays

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2038277

Cite this

Lukianova-Hleb, E. Y., Ren, X., Sawant, R. R., Gillenwater, A. M., Kupferman, M., Hanna, E. Y., Zasadzinski, J. A., Wu, X., Torchilin, V. P., & Lapotko, D. O. (2014). Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma. In Photonic Therapeutics and Diagnostics X Article 89262D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8926). SPIE. https://doi.org/10.1117/12.2038277

Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma. / Lukianova-Hleb, Ekaterina Y.; Ren, Xiaoyang; Sawant, Rupa R. et al.
Photonic Therapeutics and Diagnostics X. SPIE, 2014. 89262D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8926).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lukianova-Hleb, EY, Ren, X, Sawant, RR, Gillenwater, AM, Kupferman, M, Hanna, EY, Zasadzinski, JA, Wu, X, Torchilin, VP & Lapotko, DO 2014, Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma. in Photonic Therapeutics and Diagnostics X., 89262D, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8926, SPIE, Photonic Therapeutics and Diagnostics X, San Francisco, CA, United States, 2/1/14. https://doi.org/10.1117/12.2038277

@inproceedings{81720edb24a84077a3dd5334d0b4a444,

title = "Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma",

abstract = "Chemoradiation-resistant cancer cells and unresectable micro-tumors limit treatment efficacy and lead to high nonspecific toxicity or recurrence in head and neck cancers. We show the cancer cell-specific, on-demand enhancement of the chemo- and chemoradiation therapy with mechanical intracellular impact of plasmonic nanobubbles, a laser pulseinduced explosive nano-event, not a particle. We report cellular mechanisms of cancer cell-specific detection and enhancement of the entry drug and X-ray dose and validate these mechanisms in vitro and in vivo for head and neck squamous cell carcinoma. Plasmonic nanobubble technology showed more than 10-fold enhancement of the therapeutic efficacy compared to standard chemoradiation in murine models of primary, microscopic residual and recurrent diseases. At the same time our technology efficiently spared adjacent normal tissues due to the reduction of the effective therapeutic doses of drug by 30-40 fold, X-rays by 15-fold and the treatment time to a single procedure. The developed plasmonic nanobubble technology transforms a standard macro-therapy into a cell-level on-demand theranostic treatment for primary, adjuvant and adjunct applications.",

keywords = "Drug carrier, Gold nanoparticle, Laser, Plasmonic nanobubble, X-rays",

author = "Lukianova-Hleb, {Ekaterina Y.} and Xiaoyang Ren and Sawant, {Rupa R.} and Gillenwater, {Ann M.} and Michael Kupferman and Hanna, {Ehab Y.} and Zasadzinski, {Joseph A.} and Xiangwei Wu and Torchilin, {Vladimir P.} and Lapotko, {Dmitri O.}",

year = "2014",

doi = "10.1117/12.2038277",

language = "English (US)",

isbn = "9780819498397",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

booktitle = "Photonic Therapeutics and Diagnostics X",

note = "Photonic Therapeutics and Diagnostics X ; Conference date: 01-02-2014 Through 02-02-2014",

}

TY - GEN

T1 - Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma

AU - Lukianova-Hleb, Ekaterina Y.

AU - Ren, Xiaoyang

AU - Sawant, Rupa R.

AU - Gillenwater, Ann M.

AU - Kupferman, Michael

AU - Hanna, Ehab Y.

AU - Zasadzinski, Joseph A.

AU - Wu, Xiangwei

AU - Torchilin, Vladimir P.

AU - Lapotko, Dmitri O.

PY - 2014

Y1 - 2014

N2 - Chemoradiation-resistant cancer cells and unresectable micro-tumors limit treatment efficacy and lead to high nonspecific toxicity or recurrence in head and neck cancers. We show the cancer cell-specific, on-demand enhancement of the chemo- and chemoradiation therapy with mechanical intracellular impact of plasmonic nanobubbles, a laser pulseinduced explosive nano-event, not a particle. We report cellular mechanisms of cancer cell-specific detection and enhancement of the entry drug and X-ray dose and validate these mechanisms in vitro and in vivo for head and neck squamous cell carcinoma. Plasmonic nanobubble technology showed more than 10-fold enhancement of the therapeutic efficacy compared to standard chemoradiation in murine models of primary, microscopic residual and recurrent diseases. At the same time our technology efficiently spared adjacent normal tissues due to the reduction of the effective therapeutic doses of drug by 30-40 fold, X-rays by 15-fold and the treatment time to a single procedure. The developed plasmonic nanobubble technology transforms a standard macro-therapy into a cell-level on-demand theranostic treatment for primary, adjuvant and adjunct applications.

AB - Chemoradiation-resistant cancer cells and unresectable micro-tumors limit treatment efficacy and lead to high nonspecific toxicity or recurrence in head and neck cancers. We show the cancer cell-specific, on-demand enhancement of the chemo- and chemoradiation therapy with mechanical intracellular impact of plasmonic nanobubbles, a laser pulseinduced explosive nano-event, not a particle. We report cellular mechanisms of cancer cell-specific detection and enhancement of the entry drug and X-ray dose and validate these mechanisms in vitro and in vivo for head and neck squamous cell carcinoma. Plasmonic nanobubble technology showed more than 10-fold enhancement of the therapeutic efficacy compared to standard chemoradiation in murine models of primary, microscopic residual and recurrent diseases. At the same time our technology efficiently spared adjacent normal tissues due to the reduction of the effective therapeutic doses of drug by 30-40 fold, X-rays by 15-fold and the treatment time to a single procedure. The developed plasmonic nanobubble technology transforms a standard macro-therapy into a cell-level on-demand theranostic treatment for primary, adjuvant and adjunct applications.

KW - Drug carrier

KW - Gold nanoparticle

KW - Laser

KW - Plasmonic nanobubble

KW - X-rays

UR - http://www.scopus.com/inward/record.url?scp=84897510532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897510532&partnerID=8YFLogxK

U2 - 10.1117/12.2038277

DO - 10.1117/12.2038277

M3 - Conference contribution

AN - SCOPUS:84897510532

SN - 9780819498397

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics X

PB - SPIE

T2 - Photonic Therapeutics and Diagnostics X

Y2 - 1 February 2014 through 2 February 2014

ER -

Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this