@inproceedings{5fa4dfae1168438992f433b29c455582,
title = "Plasmonic nanobubbles as tunable theranostic agents",
abstract = "Theranostic applications require coupling of diagnosis and therapy, a high degree of specificity and adaptability to delivery methods compatible with clinical practice. The tunable physical and biological effects of selective targeting and activation of plasmonic nanobubbles (PNB) were studied in a heterogeneous biological microenvironment of prostate cancer and stromal cells. All cells were targeted with conjugates of gold nanoparticles (NPs) through an antibody-receptor-endocytosis-nanocluster mechanism that produced NP clusters. The simultaneous pulsed optical activation of intracellular NP clusters at several wavelengths resulted in higher optical contrast and therapeutic selectivity of PNBs compared with those of gold nanoparticles alone. The developed mechanism was termed {"}rainbow plasmonic nanobubbles.{"} The cellular effect of rainbow PNBs was tuned in situ in target cells, thus supporting a theranostic algorithm of prostate cancer cell detection and follow-up guided destruction without damage to collateral cells. The specificity and tunability of PNBs is promising for theranostic applications and we discuss a fiber optic platform that will capitalize on these features to bring theranostic tools to the clinic.",
keywords = "Cancer, Gold nanoparticles, Laser, Plasmonic nanobubbles, Theranostics",
author = "E. Lukianova-Hleb and P. Constantinou and B. Danysh and Wagner, {D. S.} and Drezek, {R. A.} and Hafner, {J. H.} and Farach-Carson, {M. C.} and Carson, {D. D.} and Dmitri Lapotko",
note = "Copyright: Copyright 2011 Elsevier B.V., All rights reserved.; Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 ; Conference date: 13-06-2011 Through 16-06-2011",
year = "2011",
language = "English (US)",
isbn = "9781439871386",
series = "Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011",
pages = "367--370",
booktitle = "Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011",
}