TY - JOUR
T1 - Plasticity of cancer invasion and energy metabolism
AU - Parlani, Maria
AU - Jorgez, Carolina
AU - Friedl, Peter
N1 - Funding Information:
We thank Konstantinos Konstantopoulos for expert discussion and Mirjam Zegers for critical reading and helpful comments on the manuscript. The work of the laboratory was supported by grants from the European Research Council ( ERC-AdG-2021-101054921 ), the National Institutes of Health (NIH; U54 CA210184-01 and U54 CA261694-01 ) and the EU (ITN-Inflanet EU-H2020-ITN 955576 ).
Publisher Copyright:
© 2023 The Authors
PY - 2023/5
Y1 - 2023/5
N2 - Energy deprivation is a frequent adverse event in tumors that is caused by mutations, malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to signaling and metabolic adaptation responses in tumor cells, secures survival, and adjusts migration activity. The kinetic responses of cancer cells to energy deficit were recently identified, including a switch of invasive cancer cells to energy-conservative amoeboid migration and an enhanced capability for distant metastasis. We review the energy programs employed by different cancer invasion modes including collective, mesenchymal, and amoeboid migration, as well as their interconversion in response to energy deprivation, and we discuss the consequences for metastatic escape. Understanding the energy requirements of amoeboid and other dissemination strategies offers rationales for improving therapeutic targeting of metastatic cancer progression.
AB - Energy deprivation is a frequent adverse event in tumors that is caused by mutations, malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to signaling and metabolic adaptation responses in tumor cells, secures survival, and adjusts migration activity. The kinetic responses of cancer cells to energy deficit were recently identified, including a switch of invasive cancer cells to energy-conservative amoeboid migration and an enhanced capability for distant metastasis. We review the energy programs employed by different cancer invasion modes including collective, mesenchymal, and amoeboid migration, as well as their interconversion in response to energy deprivation, and we discuss the consequences for metastatic escape. Understanding the energy requirements of amoeboid and other dissemination strategies offers rationales for improving therapeutic targeting of metastatic cancer progression.
KW - amoeboid migration
KW - cellular bioenergetics
KW - metabolic stress
KW - migration plasticity
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U2 - 10.1016/j.tcb.2022.09.009
DO - 10.1016/j.tcb.2022.09.009
M3 - Review article
C2 - 36328835
AN - SCOPUS:85140975799
SN - 0962-8924
VL - 33
SP - 388
EP - 402
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 5
ER -