TY - JOUR
T1 - Plasticity of Cell Migration in Vivo and in Silico
AU - Te Boekhorst, Veronika
AU - Preziosi, Luigi
AU - Friedl, Peter
N1 - Publisher Copyright:
© 2016 by Annual Reviews. All rights reserved.
PY - 2016/10/6
Y1 - 2016/10/6
N2 - Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. Mechanistic principles that determine single-cell and collective migration modes and their interconversions depend upon the polarization, adhesion, deformability, contractility, and proteolytic ability of cells. Cellular determinants of cell migration respond to extracellular cues, including tissue composition, topography, alignment, and tissue-associated growth factors and cytokines. Both cellular determinants and tissue determinants are interdependent; undergo reciprocal adjustment; and jointly impact cell decision making, navigation, and migration outcome in complex environments. We here review the variability, decision making, and adaptation of cell migration approached by live-cell, in vivo, and in silico strategies, with a focus on cell movements in morphogenesis, repair, immune surveillance, and cancer metastasis.
AB - Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. Mechanistic principles that determine single-cell and collective migration modes and their interconversions depend upon the polarization, adhesion, deformability, contractility, and proteolytic ability of cells. Cellular determinants of cell migration respond to extracellular cues, including tissue composition, topography, alignment, and tissue-associated growth factors and cytokines. Both cellular determinants and tissue determinants are interdependent; undergo reciprocal adjustment; and jointly impact cell decision making, navigation, and migration outcome in complex environments. We here review the variability, decision making, and adaptation of cell migration approached by live-cell, in vivo, and in silico strategies, with a focus on cell movements in morphogenesis, repair, immune surveillance, and cancer metastasis.
KW - Amoeboid migration
KW - Cell adhesion
KW - Collective movement
KW - Mathematical modeling
KW - Mesenchymal migration
KW - Proteolysis
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U2 - 10.1146/annurev-cellbio-111315-125201
DO - 10.1146/annurev-cellbio-111315-125201
M3 - Review article
C2 - 27576118
AN - SCOPUS:84990854130
SN - 1081-0706
VL - 32
SP - 491
EP - 526
JO - Annual Review of Cell and Developmental Biology
JF - Annual Review of Cell and Developmental Biology
ER -