TY - JOUR
T1 - Platelet effects on ovarian cancer
AU - Davis, Ashley N.
AU - Afshar-Kharghan, Vahid
AU - Sood, Anil K.
N1 - Funding Information:
Portions of this work were supported by the NIH (CA177909, CA016672, CA109298, P50 CA083639, P50 CA098258, U54 CA151668, and UH2 TR000943), the DOD (OC120547 and OC093416), the Ovarian Cancer Research Fund (Program Project Development Grant), Meyer and Ida Gordon Foundation #2, the Blanton-Davis Ovarian Cancer Research Program, the Chapman Foundation, the RGK Foundation, the Gilder Foundation, and the Betty Anne Asche Murray Distinguished Professorship.
PY - 2014/6
Y1 - 2014/6
N2 - Growing understanding of the role of thrombocytosis, high platelet turnover, and the presence of activated platelets in the circulation in cancer progression and metastasis has brought megakaryocytes into focus. Platelet biology is essential to hemostasis, vascular integrity, angiogenesis, inflammation, innate immunity, wound healing, and cancer biology. However, before megakaryocyte/platelet-directed therapies can be considered for clinical use, understanding of the mechanism and biology of paraneoplastic thrombocytosis in malignancy is required. Here, we provide an overview of the clinical implications, biological significance, and mechanisms of paraneoplastic thrombocytosis in the context of ovarian cancer.
AB - Growing understanding of the role of thrombocytosis, high platelet turnover, and the presence of activated platelets in the circulation in cancer progression and metastasis has brought megakaryocytes into focus. Platelet biology is essential to hemostasis, vascular integrity, angiogenesis, inflammation, innate immunity, wound healing, and cancer biology. However, before megakaryocyte/platelet-directed therapies can be considered for clinical use, understanding of the mechanism and biology of paraneoplastic thrombocytosis in malignancy is required. Here, we provide an overview of the clinical implications, biological significance, and mechanisms of paraneoplastic thrombocytosis in the context of ovarian cancer.
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U2 - 10.1053/j.seminoncol.2014.04.004
DO - 10.1053/j.seminoncol.2014.04.004
M3 - Article
C2 - 25023353
AN - SCOPUS:84904152982
SN - 0093-7754
VL - 41
SP - 378
EP - 384
JO - Seminars in oncology
JF - Seminars in oncology
IS - 3
ER -