Abstract
In this review we have presentd overwhelming evidence that platelets play an important enhancing role in tumor cell-vasculature interactions and cancer metastasis. Tumor cells employ a host of mechanisms to induce platelet aggregation; vice versa, platelets make use of a spectrum of mechanisms to modulate tumor cell-EC and tumor cell-ECM interactions. Various COX and LOX metabolites are closely involved in this bidirectional modulation, thus providing us with a very promising therapeutic avenue by modifying the actions of these metabolites. On the other hand, adhesion molecules are mediators of tumor cell-platelet-EC interactions; therefore interference with these adhesion molecules and various adhesive processes either by soluble peptides, non-peptidic analogues, or specific antibodies holds great investigational and clinical appeal.
Original language | English (US) |
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Pages (from-to) | 392-415 |
Number of pages | 24 |
Journal | Seminars in Thrombosis and Hemostasis |
Volume | 18 |
Issue number | 4 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- Hematology
- Cardiology and Cardiovascular Medicine