Abstract
Chemotherapy has had limited success in the treatment of cancer over the years, due, in part, to the untoward toxicity of the therapeutic agent to normal cells. The design of tailor-made polymer conjugates provides a synthetic approach that can overcome some of the problems. Several synthetic polymer-based anticancer drug conjugates have entered clinical studies. This report reviews the chemistry, physicochemical properties, and therapeutic applications in cancer therapy of polymeric chemotherapeutic agents based on poly(L-glutamic acid). Targeted delivery of anticancer agents using poly(L-glutamic acid) as the drug carrier is also discussed with emphasis on the design of innovative polymeric constructs.
Original language | English (US) |
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Pages (from-to) | 695-713 |
Number of pages | 19 |
Journal | Advanced Drug Delivery Reviews |
Volume | 54 |
Issue number | 5 |
DOIs | |
State | Published - Sep 13 2002 |
Keywords
- Anticancer drugs
- Drug targeting
- Enhanced permeability and retention effect
- Poly(L-glutamic acid)
- Polymer-drug conjugates
ASJC Scopus subject areas
- Pharmaceutical Science