Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt

Sherif Z. Abdel-Rahman; Amr S. Soliman; Melissa L. Bondy; Xifeng Wu; Samy A. El-Badawy; Khaled G. Mahgoub; Sohair Ismail; Ibrahim A. Seifeldin; Bernard Levin

doi:10.1016/S0304-3835(99)00159-7

Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt

Sherif Z. Abdel-Rahman, Amr S. Soliman, Melissa L. Bondy, Xifeng Wu, Samy A. El-Badawy, Khaled G. Mahgoub, Sohair Ismail, Ibrahim A. Seifeldin, Bernard Levin

Epidemiology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Egypt has an unusually high proportion of early-onset colorectal cancer under age 40 years. Environmental exposures and low DNA repair capacity are among the risk factors. Because GSTM1 and GSTT1 gene deficiencies may act as risk modifiers for colorectal cancer risk, we investigated the relationship between genetic polymorphism in these genes and colorectal cancer risk in Egyptians. Sixty-six patients and 55 controls were included. Genotyping for GSTM1 and GSTT1 was conducted using PCR techniques and the results were related to epidemiologic and clinical information. No overall association was observed between GSTM1 or GSTT1 null genotypes and colorectal cancer risk. However, the data suggest a possible role for GSTM1 genotype in influencing tumor site. Furthermore, GSTM1 and GSTT1 genotypes, in conjunction with gender and place of residence, may play a role in modifying disease risk. Further studies on a larger population in Egypt are needed to generalize the results of this study. Copyright (C) 1999.

Original language	English (US)
Pages (from-to)	97-104
Number of pages	8
Journal	Cancer Letters
Volume	142
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(99)00159-7
State	Published - Jul 19 1999

Keywords

Colon cancer
Egypt
GSTM1
GSTT1
Genetic polymorphism
Glutathione S-transferase

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt",

abstract = "Egypt has an unusually high proportion of early-onset colorectal cancer under age 40 years. Environmental exposures and low DNA repair capacity are among the risk factors. Because GSTM1 and GSTT1 gene deficiencies may act as risk modifiers for colorectal cancer risk, we investigated the relationship between genetic polymorphism in these genes and colorectal cancer risk in Egyptians. Sixty-six patients and 55 controls were included. Genotyping for GSTM1 and GSTT1 was conducted using PCR techniques and the results were related to epidemiologic and clinical information. No overall association was observed between GSTM1 or GSTT1 null genotypes and colorectal cancer risk. However, the data suggest a possible role for GSTM1 genotype in influencing tumor site. Furthermore, GSTM1 and GSTT1 genotypes, in conjunction with gender and place of residence, may play a role in modifying disease risk. Further studies on a larger population in Egypt are needed to generalize the results of this study. Copyright (C) 1999.",

keywords = "Colon cancer, Egypt, GSTM1, GSTT1, Genetic polymorphism, Glutathione S-transferase",

author = "Abdel-Rahman, {Sherif Z.} and Soliman, {Amr S.} and Bondy, {Melissa L.} and Xifeng Wu and El-Badawy, {Samy A.} and Mahgoub, {Khaled G.} and Sohair Ismail and Seifeldin, {Ibrahim A.} and Bernard Levin",

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doi = "10.1016/S0304-3835(99)00159-7",

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T1 - Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt

AU - Abdel-Rahman, Sherif Z.

AU - Soliman, Amr S.

AU - Bondy, Melissa L.

AU - Wu, Xifeng

AU - El-Badawy, Samy A.

AU - Mahgoub, Khaled G.

AU - Ismail, Sohair

AU - Seifeldin, Ibrahim A.

AU - Levin, Bernard

PY - 1999/7/19

Y1 - 1999/7/19

N2 - Egypt has an unusually high proportion of early-onset colorectal cancer under age 40 years. Environmental exposures and low DNA repair capacity are among the risk factors. Because GSTM1 and GSTT1 gene deficiencies may act as risk modifiers for colorectal cancer risk, we investigated the relationship between genetic polymorphism in these genes and colorectal cancer risk in Egyptians. Sixty-six patients and 55 controls were included. Genotyping for GSTM1 and GSTT1 was conducted using PCR techniques and the results were related to epidemiologic and clinical information. No overall association was observed between GSTM1 or GSTT1 null genotypes and colorectal cancer risk. However, the data suggest a possible role for GSTM1 genotype in influencing tumor site. Furthermore, GSTM1 and GSTT1 genotypes, in conjunction with gender and place of residence, may play a role in modifying disease risk. Further studies on a larger population in Egypt are needed to generalize the results of this study. Copyright (C) 1999.

AB - Egypt has an unusually high proportion of early-onset colorectal cancer under age 40 years. Environmental exposures and low DNA repair capacity are among the risk factors. Because GSTM1 and GSTT1 gene deficiencies may act as risk modifiers for colorectal cancer risk, we investigated the relationship between genetic polymorphism in these genes and colorectal cancer risk in Egyptians. Sixty-six patients and 55 controls were included. Genotyping for GSTM1 and GSTT1 was conducted using PCR techniques and the results were related to epidemiologic and clinical information. No overall association was observed between GSTM1 or GSTT1 null genotypes and colorectal cancer risk. However, the data suggest a possible role for GSTM1 genotype in influencing tumor site. Furthermore, GSTM1 and GSTT1 genotypes, in conjunction with gender and place of residence, may play a role in modifying disease risk. Further studies on a larger population in Egypt are needed to generalize the results of this study. Copyright (C) 1999.

KW - Colon cancer

KW - Egypt

KW - GSTM1

KW - GSTT1

KW - Genetic polymorphism

KW - Glutathione S-transferase

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Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt

Abstract

Keywords

ASJC Scopus subject areas

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