TY - JOUR
T1 - Polymorphisms in the vitamin D receptor gene and type 1 diabetes mellitus risk
T2 - An update by meta-analysis
AU - Zhang, Jie
AU - Li, Wei
AU - Liu, Jiaming
AU - Wu, Wenhe
AU - Ouyang, Houxian
AU - Zhang, Qingqing
AU - Wang, Yue
AU - Liu, Libin
AU - Yang, Rongrong
AU - Liu, Xiaoting
AU - Meng, Qinghe
AU - Lu, Jianxin
N1 - Funding Information:
This study was supported by the National Science and Technology Major Project of China ( 2008ZX10003-003 ), the National High Technology Research and Development Program of China (863) ( 2007AA022008 ), the Zhejiang Provincial Science and Technology Major Project ( 2009C13038 ), the National Natural Science Foundation of China ( 81071426 , 30871362 ), the Natural Science Foundation of Zhejiang Province, China ( D2080910 , Y2081072 ), Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents and Key Laboratory of Laboratory Medicine, Ministry of Education , and Key Science and Technology Innovation Team of Zhejiang Province ( 2010R50048 ).
PY - 2012/5/15
Y1 - 2012/5/15
N2 - Four well known polymorphisms (BsmI, FokI, ApaI, TaqI) in the VDR gene have been implicated in susceptibility to type 1 diabetes mellitus (T1DM), but the results to date have been inconclusive. The aim of this study was to investigate the association between polymorphisms in the VDR gene and T1DM risk by meta-analysis. A total of 57 case-control studies in 26 published studies were included. The results indicated that the BsmI polymorphism is associated with increased risk of T1DM (BB. +. Bb vs. bb: OR. =1.30, 95% CI. =1.03-1.63), while the FokI, ApaI and TaqI polymorphisms were not. In the subgroup analysis by ethnicity, the increased risk of T1DM remained in the Asian subgroup for the BsmI polymorphism; whereas no significant association was found in other populations for other polymorphisms. Results from the current study suggest that the BsmI polymorphism is associated with increased risk of T1DM, especially in Asians. Further studies are needed to confirm our results.
AB - Four well known polymorphisms (BsmI, FokI, ApaI, TaqI) in the VDR gene have been implicated in susceptibility to type 1 diabetes mellitus (T1DM), but the results to date have been inconclusive. The aim of this study was to investigate the association between polymorphisms in the VDR gene and T1DM risk by meta-analysis. A total of 57 case-control studies in 26 published studies were included. The results indicated that the BsmI polymorphism is associated with increased risk of T1DM (BB. +. Bb vs. bb: OR. =1.30, 95% CI. =1.03-1.63), while the FokI, ApaI and TaqI polymorphisms were not. In the subgroup analysis by ethnicity, the increased risk of T1DM remained in the Asian subgroup for the BsmI polymorphism; whereas no significant association was found in other populations for other polymorphisms. Results from the current study suggest that the BsmI polymorphism is associated with increased risk of T1DM, especially in Asians. Further studies are needed to confirm our results.
KW - Meta-analysis
KW - Polymorphisms
KW - Type 1 diabetes mellitus
KW - Vitamin D receptor gene
UR - http://www.scopus.com/inward/record.url?scp=84862808322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862808322&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2012.02.003
DO - 10.1016/j.mce.2012.02.003
M3 - Article
C2 - 22361322
AN - SCOPUS:84862808322
SN - 0303-7207
VL - 355
SP - 135
EP - 142
JO - Molecular and cellular endocrinology
JF - Molecular and cellular endocrinology
IS - 1
ER -