TY - JOUR
T1 - Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of gastric cancer in a Chinese population
T2 - A case-control study
AU - Shen, Hongbing
AU - Xu, Yaochu
AU - Zheng, Yuxin
AU - Qian, Yun
AU - Yu, Rongbin
AU - Qin, Yu
AU - Wang, Xinru
AU - Spitz, Margaret R.
AU - Wei, Qingyi
PY - 2001/9/20
Y1 - 2001/9/20
N2 - Low dietary folate intake has been associated with increased risk of gastric cancer. The 5, 10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and AI298C, that result in decreased MTHFR activity and lower plasma folate levels. Therefore, we hypothesized that these 2 variants play a role in gastric carcinogenesis. We tested this hypothesis in a Chinese population-based case-control study of 187 histopathologically confirmed gastric cancer cases and 166 healthy controls frequency-matched by age (±5 years), gender and residential area. The 677TT genotype was associated with increased risk for gastric cancer [adjusted odds ratio (OR) = 1.87, 95% confidence interval (CI) = 1.00-3.48] compared to the 677CC genotype. This association was more pronounced for gastric cardia cancer (adjusted OR = 2.47, 95% CI = 1.14-5.32). However, no evidence was found for risk associated with the MTHFR AI298C polymorphism. Our findings support the hypothesis that MTHFR C677T variants contribute to gastric carcinogenesis, particularly in gastric cardia. Larger studies incorporating dietary folate intake and serum levels are needed to confirm our findings.
AB - Low dietary folate intake has been associated with increased risk of gastric cancer. The 5, 10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and AI298C, that result in decreased MTHFR activity and lower plasma folate levels. Therefore, we hypothesized that these 2 variants play a role in gastric carcinogenesis. We tested this hypothesis in a Chinese population-based case-control study of 187 histopathologically confirmed gastric cancer cases and 166 healthy controls frequency-matched by age (±5 years), gender and residential area. The 677TT genotype was associated with increased risk for gastric cancer [adjusted odds ratio (OR) = 1.87, 95% confidence interval (CI) = 1.00-3.48] compared to the 677CC genotype. This association was more pronounced for gastric cardia cancer (adjusted OR = 2.47, 95% CI = 1.14-5.32). However, no evidence was found for risk associated with the MTHFR AI298C polymorphism. Our findings support the hypothesis that MTHFR C677T variants contribute to gastric carcinogenesis, particularly in gastric cardia. Larger studies incorporating dietary folate intake and serum levels are needed to confirm our findings.
KW - Folate intake
KW - Gastric cancer
KW - Genetic polymorphism
KW - Methylenetetrahydrofolate reductase
KW - Molecular epidemiology
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U2 - 10.1002/1097-0215(20010920)95:5<332::AID-IJC1058>3.0.CO;2-9
DO - 10.1002/1097-0215(20010920)95:5<332::AID-IJC1058>3.0.CO;2-9
M3 - Article
C2 - 11494235
AN - SCOPUS:0035922101
SN - 0020-7136
VL - 95
SP - 332
EP - 336
JO - International journal of cancer
JF - International journal of cancer
IS - 5
ER -