TY - JOUR
T1 - Polymorphisms of progesterone receptor and ovarian cancer risk
T2 - A systemic review and meta-analysis
AU - Liao, Jing
AU - Ding, Dong
AU - Sun, Chaoyang
AU - Weng, Danhui
AU - Meng, Li
AU - Chen, Gang
AU - Ma, Ding
N1 - Publisher Copyright:
© 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Aim Growing bodies of studies have investigated the associations between three progesterone receptor (PGR) polymorphisms, +331G/A, Alu insertion and Val660Leu, and susceptibility to ovarian cancer, but the results remain controversial and inconclusive. Thus, we conducted a meta-analysis to derive a more precise estimation of the associations. Methods A total of 21 case-control studies from 16 publications that included analyses of Alu insertion (981 cases, 2136 controls), Val660Leu (2205 cases, 3222 controls) and +331G/A (2842 cases, 4305 controls) polymorphisms were identified. Results Significantly increased risks of ovarian cancer were found for Alu insertion (T2 T2 + T1T2 vs T1T1; odds ratio [OR], 1.504; 95% confidence interval [CI], 1.206-2.203) and Val660Leu (TT vs GT; OR, 1.524; 95% CI, 1.013-2.293). No significant association was found between +331G/A polymorphism and ovarian cancer. Conclusion This meta-analysis suggests that the two polymorphisms of PGR, Alu insertion and Val660Leu, may contribute to ovarian cancer susceptibility as low-penetrance risk factors.
AB - Aim Growing bodies of studies have investigated the associations between three progesterone receptor (PGR) polymorphisms, +331G/A, Alu insertion and Val660Leu, and susceptibility to ovarian cancer, but the results remain controversial and inconclusive. Thus, we conducted a meta-analysis to derive a more precise estimation of the associations. Methods A total of 21 case-control studies from 16 publications that included analyses of Alu insertion (981 cases, 2136 controls), Val660Leu (2205 cases, 3222 controls) and +331G/A (2842 cases, 4305 controls) polymorphisms were identified. Results Significantly increased risks of ovarian cancer were found for Alu insertion (T2 T2 + T1T2 vs T1T1; odds ratio [OR], 1.504; 95% confidence interval [CI], 1.206-2.203) and Val660Leu (TT vs GT; OR, 1.524; 95% CI, 1.013-2.293). No significant association was found between +331G/A polymorphism and ovarian cancer. Conclusion This meta-analysis suggests that the two polymorphisms of PGR, Alu insertion and Val660Leu, may contribute to ovarian cancer susceptibility as low-penetrance risk factors.
KW - meta-analysis
KW - ovarian cancer
KW - ovarian cancer risk
KW - polymorphism
KW - progesterone receptor
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U2 - 10.1111/jog.12519
DO - 10.1111/jog.12519
M3 - Review article
C2 - 25228088
AN - SCOPUS:84921629093
SN - 1341-8076
VL - 41
SP - 178
EP - 187
JO - Journal of Obstetrics and Gynaecology Research
JF - Journal of Obstetrics and Gynaecology Research
IS - 2
ER -