TY - JOUR
T1 - Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population
AU - Shen, Hongbing
AU - Xu, Yaochu
AU - Qian, Yun
AU - Yu, Rongbin
AU - Qin, Yu
AU - Zhou, Ling
AU - Wang, Xinru
AU - Spitz, Margaret R.
AU - Wei, Qingyi
PY - 2000
Y1 - 2000
N2 - Gastric cancer remains the leading cause of cancer death in China and other countries in eastern Asia. Studies of gastric cancer have revealed that it is a disease of complex etiology involving dietary, infectious, environmental, occupational and genetic factors. DNA repair capacity has been suggested as a genetic factor contributing to variation in susceptibility to cancer. In the present study, we described an association between 2 polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. We used a polymerase chain reaction-based assay to detect Pvu II and Nci I restriction fragment length polymorphisms (XRCC1 26304 C→T and XRCC1 28152 G→A, respectively) in 188 patients with gastric cancer and 166 healthy controls. The XRCC1 26304 T allele (194Trp) frequency (34.6%) was higher and the XRCC1 28152 A allele (399Gln) frequency (25.6%) was lower in healthy Chinese controls than previously reported healthy U.S. Caucasian controls (7.2% and 34.1%, respectively). Multivariate logistic regression analysis revealed that the putative high-risk geno-types XRCC1 26304 CC and XRCC1 281S2 GA/AA were associated with a non-significant increased risk for gastric cancer (adjusted odds ratio [OR] = 1.45, 95% confidence interval [Cl] = 0.93-2.25 and OR = 1.53, 95% Cl = 0.98-2.39, respectively) compared with other genotypes. However, the XRCC1 26304 CC genotype was associated with a significantly increased risk for gastric cardia cancer (adjusted OR = 1.86, 95% Cl = 1.09-3.20). Individuals with both putative high-risk geno-types (CC and GA/AA) had a significantly higher risk (adjusted OR = 1.73, 95% Cl = 1.12-2.69), particularly for gastric cardia cancer (adjusted OR = 2.18, 95% Cl = 1.21-3.94) than individuals with other genotypes. These findings support the hypothesis that these 2 XRCC1 variants may contribute to the risk of developing gastric cancer, particularly gastric cardia cancer. (C) 2000 Wiley-Liss, Inc.
AB - Gastric cancer remains the leading cause of cancer death in China and other countries in eastern Asia. Studies of gastric cancer have revealed that it is a disease of complex etiology involving dietary, infectious, environmental, occupational and genetic factors. DNA repair capacity has been suggested as a genetic factor contributing to variation in susceptibility to cancer. In the present study, we described an association between 2 polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. We used a polymerase chain reaction-based assay to detect Pvu II and Nci I restriction fragment length polymorphisms (XRCC1 26304 C→T and XRCC1 28152 G→A, respectively) in 188 patients with gastric cancer and 166 healthy controls. The XRCC1 26304 T allele (194Trp) frequency (34.6%) was higher and the XRCC1 28152 A allele (399Gln) frequency (25.6%) was lower in healthy Chinese controls than previously reported healthy U.S. Caucasian controls (7.2% and 34.1%, respectively). Multivariate logistic regression analysis revealed that the putative high-risk geno-types XRCC1 26304 CC and XRCC1 281S2 GA/AA were associated with a non-significant increased risk for gastric cancer (adjusted odds ratio [OR] = 1.45, 95% confidence interval [Cl] = 0.93-2.25 and OR = 1.53, 95% Cl = 0.98-2.39, respectively) compared with other genotypes. However, the XRCC1 26304 CC genotype was associated with a significantly increased risk for gastric cardia cancer (adjusted OR = 1.86, 95% Cl = 1.09-3.20). Individuals with both putative high-risk geno-types (CC and GA/AA) had a significantly higher risk (adjusted OR = 1.73, 95% Cl = 1.12-2.69), particularly for gastric cardia cancer (adjusted OR = 2.18, 95% Cl = 1.21-3.94) than individuals with other genotypes. These findings support the hypothesis that these 2 XRCC1 variants may contribute to the risk of developing gastric cancer, particularly gastric cardia cancer. (C) 2000 Wiley-Liss, Inc.
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U2 - 10.1002/1097-0215(20001115)88:4<601::AID-IJC13>3.0.CO;2-C
DO - 10.1002/1097-0215(20001115)88:4<601::AID-IJC13>3.0.CO;2-C
M3 - Article
C2 - 11058877
AN - SCOPUS:0033761625
SN - 0020-7136
VL - 88
SP - 601
EP - 606
JO - International journal of cancer
JF - International journal of cancer
IS - 4
ER -