TY - JOUR
T1 - Polyphenolics in ramontchi protect cardiac tissues via suppressing isoprenaline-induced oxidative stress and inflammatory responses in Long-Evans rats
AU - Akter, Noushin
AU - Chowdhury, Faizul Islam
AU - Selim, Saima
AU - Nayan, Shariful Islam
AU - Khan, Ferdous
AU - Subhan, Nusrat
AU - Hossain, Hemayet
AU - Rahman, Md Mizanur
AU - Haque, Md Areeful
AU - Alam, Md Ashraful
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/12
Y1 - 2020/12
N2 - This investigation was aimed to explore the cardioprotective effect of Ramontchi fruits (Flacourtia indica; FI) in isoprenaline-administered Long-Evans rats. Administration of isoprenaline increased the total heart wet weight, MDA, NO, and APOP as well as ALT, AST, and CK-MB levels, which were normalized by FI fruits treatment. Moreover, expressions of antioxidant genes i.e., Nrf-2, HO-1, HO-2, SOD, catalase, and GPx were normalized by FI fruits in isoprenaline-induced rats. Besides, expression of inflammatory mediators i.e., IL-1, IL-6, TNF-α, TGF-β, iNOS, and NF-κB were also suppressed by FI fruits. The outcome of FI fruits treatment was noted as promising and comparable to the standard atenolol treatment. The enhanced biological activity shown by FI fruits may be due to its abundant polyphenolic compounds as determined by HPLC analysis. In conclusion, FI fruits may protect cardiac tissue in isoprenaline-administered rats by suppressing the oxidative stress and proinflammatory mediators and enhancing the antioxidant enzyme functions.
AB - This investigation was aimed to explore the cardioprotective effect of Ramontchi fruits (Flacourtia indica; FI) in isoprenaline-administered Long-Evans rats. Administration of isoprenaline increased the total heart wet weight, MDA, NO, and APOP as well as ALT, AST, and CK-MB levels, which were normalized by FI fruits treatment. Moreover, expressions of antioxidant genes i.e., Nrf-2, HO-1, HO-2, SOD, catalase, and GPx were normalized by FI fruits in isoprenaline-induced rats. Besides, expression of inflammatory mediators i.e., IL-1, IL-6, TNF-α, TGF-β, iNOS, and NF-κB were also suppressed by FI fruits. The outcome of FI fruits treatment was noted as promising and comparable to the standard atenolol treatment. The enhanced biological activity shown by FI fruits may be due to its abundant polyphenolic compounds as determined by HPLC analysis. In conclusion, FI fruits may protect cardiac tissue in isoprenaline-administered rats by suppressing the oxidative stress and proinflammatory mediators and enhancing the antioxidant enzyme functions.
KW - Antioxidant enzymes
KW - Cardioprotective effect
KW - Inflammatory genes
KW - NF-κB
KW - Polyphenols
KW - Ramontchi
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U2 - 10.1016/j.jff.2020.104250
DO - 10.1016/j.jff.2020.104250
M3 - Article
AN - SCOPUS:85092696439
SN - 1756-4646
VL - 75
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 104250
ER -