Polyploid giant cancer cells (PGCCs): The evil roots of cancer

Junsong Chen; Na Niu; Jing Zhang; Lisha Qi; Weiwei Shen; Krishna Vanaja Donkena; Zhenqing Feng; Jinsong Liu

doi:10.2174/1568009618666180703154233

Polyploid giant cancer cells (PGCCs): The evil roots of cancer

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi, Weiwei Shen, Krishna Vanaja Donkena, Zhenqing Feng, Jinsong Liu

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryo-genesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.

Original language	English (US)
Pages (from-to)	360-367
Number of pages	8
Journal	Current cancer drug targets
Volume	19
Issue number	5
DOIs	https://doi.org/10.2174/1568009618666180703154233
State	Published - 2019

Keywords

Blastomere-like cancer stem cells
Cancer stem cells
Cell fusion
Endoreplication
Polyploid giant cancer cells
Reprogramming

ASJC Scopus subject areas

Oncology
Pharmacology
Drug Discovery
Cancer Research

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10.2174/1568009618666180703154233

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title = "Polyploid giant cancer cells (PGCCs): The evil roots of cancer",

abstract = "Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryo-genesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.",

keywords = "Blastomere-like cancer stem cells, Cancer stem cells, Cell fusion, Endoreplication, Polyploid giant cancer cells, Reprogramming",

author = "Junsong Chen and Na Niu and Jing Zhang and Lisha Qi and Weiwei Shen and Donkena, {Krishna Vanaja} and Zhenqing Feng and Jinsong Liu",

note = "Funding Information: This work was supported in part by a multi-investigator grant from the Cancer Prevention and Research Institute of Texas (JL); a Sister Institution Grant from MD Anderson Cancer Center Global Academic Programs; and National Cancer Institute Cancer Center Support Grant CA016672. Publisher Copyright: {\textcopyright} 2019 Bentham Science Publishers.",

year = "2019",

doi = "10.2174/1568009618666180703154233",

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volume = "19",

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T1 - Polyploid giant cancer cells (PGCCs)

T2 - The evil roots of cancer

AU - Chen, Junsong

AU - Niu, Na

AU - Zhang, Jing

AU - Qi, Lisha

AU - Shen, Weiwei

AU - Donkena, Krishna Vanaja

AU - Feng, Zhenqing

AU - Liu, Jinsong

N1 - Funding Information: This work was supported in part by a multi-investigator grant from the Cancer Prevention and Research Institute of Texas (JL); a Sister Institution Grant from MD Anderson Cancer Center Global Academic Programs; and National Cancer Institute Cancer Center Support Grant CA016672. Publisher Copyright: © 2019 Bentham Science Publishers.

PY - 2019

Y1 - 2019

N2 - Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryo-genesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.

AB - Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryo-genesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy.

KW - Blastomere-like cancer stem cells

KW - Cancer stem cells

KW - Cell fusion

KW - Endoreplication

KW - Polyploid giant cancer cells

KW - Reprogramming

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Polyploid giant cancer cells (PGCCs): The evil roots of cancer

Abstract

Keywords

ASJC Scopus subject areas

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