Ponatinib Activates an Inflammatory Response in Endothelial Cells via ERK5 SUMOylation

Medicine & Life Sciences

• Mitogen-Activated Protein Kinase 7 100%
• ponatinib 98%
• Sumoylation 79%
• Endothelial Cells 43%
• Blood Vessels 11%
• NF-kappa B 10%
• MAP Kinase Kinase 5 10%
• Gene Expression 8%
• MAP Kinase Kinase Kinases 6%
• Vascular Endothelial Growth Factor Receptor-2 6%
• Apoptosis 6%
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive 5%
• Pulmonary Hypertension 4%
• Protein-Tyrosine Kinases 4%
• Permeability 4%
• Anti-Inflammatory Agents 3%
• Homeostasis 3%
• Up-Regulation 3%
• Phosphorylation 3%
• Phenotype 2%
• Mutation 2%
• Therapeutics 2%
• Genes 1%