Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact

Andrés Coca-Pelaz; Juan P. Rodrigo; Abbas Agaimy; Michelle Dianne Williams; Nabil F. Saba; Sandra Nuyts; Gregory W. Randolph; Fernando López; Vincent Vander Poorten; Luiz P. Kowalski; Francisco J. Civantos; Mark E. Zafereo; Antti A. Mäkitie; Oded Cohen; Iain J. Nixon; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s00428-024-03752-5

Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact

Andrés Coca-Pelaz, Juan P. Rodrigo, Abbas Agaimy, Michelle Dianne Williams, Nabil F. Saba, Sandra Nuyts, Gregory W. Randolph, Fernando López, Vincent Vander Poorten, Luiz P. Kowalski, Francisco J. Civantos, Mark E. Zafereo, Antti A. Mäkitie, Oded Cohen, Iain J. Nixon, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journal › Article › peer-review

Abstract

Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies. Recently, the 5th edition of the classification of endocrine tumors has been published, which includes changes in nomenclature and the addition of the disease entity of “differentiated high-grade follicular cell-derived carcinomas”. On the other hand, the recently witnessed advances in molecular diagnostics have enriched therapeutic options and improved prognosis for patients. We herein review the various historical variations and evolution in the diagnostic criteria for PDTC. This systematic review attempts to clarify the evolution of the histological and molecular characteristics of this disease, its prognosis, as well as its treatment options.

Original language	English (US)
Journal	Virchows Archiv
DOIs	https://doi.org/10.1007/s00428-024-03752-5
State	Accepted/In press - 2024

Keywords

High-grade follicular derived thyroid carcinoma
Outcome
Poorly differentiated thyroid cancer
Radioiodine
Treatment

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

Access to Document

10.1007/s00428-024-03752-5

Cite this

Coca-Pelaz, A., Rodrigo, J. P., Agaimy, A., Williams, M. D., Saba, N. F., Nuyts, S., Randolph, G. W., López, F., Vander Poorten, V., Kowalski, L. P., Civantos, F. J., Zafereo, M. E., Mäkitie, A. A., Cohen, O., Nixon, I. J., Rinaldo, A., & Ferlito, A. (Accepted/In press). Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact. Virchows Archiv. https://doi.org/10.1007/s00428-024-03752-5

Coca-Pelaz, A, Rodrigo, JP, Agaimy, A, Williams, MD, Saba, NF, Nuyts, S, Randolph, GW, López, F, Vander Poorten, V, Kowalski, LP, Civantos, FJ, Zafereo, ME, Mäkitie, AA, Cohen, O, Nixon, IJ, Rinaldo, A & Ferlito, A 2024, 'Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact', Virchows Archiv. https://doi.org/10.1007/s00428-024-03752-5

@article{45e379e4e6ff459dafefd338532be7ea,

title = "Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact",

abstract = "Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies. Recently, the 5th edition of the classification of endocrine tumors has been published, which includes changes in nomenclature and the addition of the disease entity of “differentiated high-grade follicular cell-derived carcinomas”. On the other hand, the recently witnessed advances in molecular diagnostics have enriched therapeutic options and improved prognosis for patients. We herein review the various historical variations and evolution in the diagnostic criteria for PDTC. This systematic review attempts to clarify the evolution of the histological and molecular characteristics of this disease, its prognosis, as well as its treatment options.",

keywords = "High-grade follicular derived thyroid carcinoma, Outcome, Poorly differentiated thyroid cancer, Radioiodine, Treatment",

author = "Andr{\'e}s Coca-Pelaz and Rodrigo, {Juan P.} and Abbas Agaimy and Williams, {Michelle Dianne} and Saba, {Nabil F.} and Sandra Nuyts and Randolph, {Gregory W.} and Fernando L{\'o}pez and {Vander Poorten}, Vincent and Kowalski, {Luiz P.} and Civantos, {Francisco J.} and Zafereo, {Mark E.} and M{\"a}kitie, {Antti A.} and Oded Cohen and Nixon, {Iain J.} and Alessandra Rinaldo and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.",

year = "2024",

doi = "10.1007/s00428-024-03752-5",

language = "English (US)",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - Poorly differentiated thyroid carcinomas

T2 - conceptual controversy and clinical impact

AU - Coca-Pelaz, Andrés

AU - Rodrigo, Juan P.

AU - Agaimy, Abbas

AU - Williams, Michelle Dianne

AU - Saba, Nabil F.

AU - Nuyts, Sandra

AU - Randolph, Gregory W.

AU - López, Fernando

AU - Vander Poorten, Vincent

AU - Kowalski, Luiz P.

AU - Civantos, Francisco J.

AU - Zafereo, Mark E.

AU - Mäkitie, Antti A.

AU - Cohen, Oded

AU - Nixon, Iain J.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

PY - 2024

Y1 - 2024

N2 - Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies. Recently, the 5th edition of the classification of endocrine tumors has been published, which includes changes in nomenclature and the addition of the disease entity of “differentiated high-grade follicular cell-derived carcinomas”. On the other hand, the recently witnessed advances in molecular diagnostics have enriched therapeutic options and improved prognosis for patients. We herein review the various historical variations and evolution in the diagnostic criteria for PDTC. This systematic review attempts to clarify the evolution of the histological and molecular characteristics of this disease, its prognosis, as well as its treatment options.

AB - Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies. Recently, the 5th edition of the classification of endocrine tumors has been published, which includes changes in nomenclature and the addition of the disease entity of “differentiated high-grade follicular cell-derived carcinomas”. On the other hand, the recently witnessed advances in molecular diagnostics have enriched therapeutic options and improved prognosis for patients. We herein review the various historical variations and evolution in the diagnostic criteria for PDTC. This systematic review attempts to clarify the evolution of the histological and molecular characteristics of this disease, its prognosis, as well as its treatment options.

KW - High-grade follicular derived thyroid carcinoma

KW - Outcome

KW - Poorly differentiated thyroid cancer

KW - Radioiodine

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85185966550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85185966550&partnerID=8YFLogxK

U2 - 10.1007/s00428-024-03752-5

DO - 10.1007/s00428-024-03752-5

M3 - Article

C2 - 38400843

AN - SCOPUS:85185966550

SN - 0945-6317

JO - Virchows Archiv

JF - Virchows Archiv

ER -

Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this