Postirradiation sarcomas in Sprague-Dawley rats

Peggy T. Tinkey; Thomas M. Lembo; Gregory R.D. Evans; Jack H. Cundiff; Kenneth N. Gray; Roger E. Price

doi:10.2307/3579704

Postirradiation sarcomas in Sprague-Dawley rats

Peggy T. Tinkey, Thomas M. Lembo, Gregory R.D. Evans, Jack H. Cundiff, Kenneth N. Gray, Roger E. Price

Veterinary Medicine & Surgery

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with ⁶⁰Co γ rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant-fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in the higher-dose groups. Tumors did not develop throughout an 8-month observation period in rats that received doses of only 0 or 46 Gy. The most common postirradiation sarcomas in humans are osteosarcoma, malignant fibrous histiocytoma and fibrosarcoma. The Sprague-Dawley rat may serve as a good animal model in studying the development of sarcoma in humans after regional radiotherapy.

Original language	English (US)
Pages (from-to)	401-404
Number of pages	4
Journal	Radiation research
Volume	149
Issue number	4
DOIs	https://doi.org/10.2307/3579704
State	Published - 1998

ASJC Scopus subject areas

Biophysics
Radiation
Radiology Nuclear Medicine and imaging

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title = "Postirradiation sarcomas in Sprague-Dawley rats",

abstract = "A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co γ rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant-fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in the higher-dose groups. Tumors did not develop throughout an 8-month observation period in rats that received doses of only 0 or 46 Gy. The most common postirradiation sarcomas in humans are osteosarcoma, malignant fibrous histiocytoma and fibrosarcoma. The Sprague-Dawley rat may serve as a good animal model in studying the development of sarcoma in humans after regional radiotherapy.",

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AU - Tinkey, Peggy T.

AU - Lembo, Thomas M.

AU - Evans, Gregory R.D.

AU - Cundiff, Jack H.

AU - Gray, Kenneth N.

AU - Price, Roger E.

PY - 1998

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AB - A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co γ rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant-fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in the higher-dose groups. Tumors did not develop throughout an 8-month observation period in rats that received doses of only 0 or 46 Gy. The most common postirradiation sarcomas in humans are osteosarcoma, malignant fibrous histiocytoma and fibrosarcoma. The Sprague-Dawley rat may serve as a good animal model in studying the development of sarcoma in humans after regional radiotherapy.

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Postirradiation sarcomas in Sprague-Dawley rats

Abstract

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