TY - JOUR
T1 - Pre-eclampsia
T2 - Connecting angiogenic and metabolic pathways
AU - Shenoy, Vivek
AU - Kanasaki, Keizo
AU - Kalluri, Raghu
N1 - Funding Information:
This work was supported by research funds from the Division of Matrix Biology, Department of Medicine at the Beth Israel Deaconess Medical Center. VS is supported by the Doris Duke Charitable Foundation.
PY - 2010/9
Y1 - 2010/9
N2 - Pre-eclampsia is a hypertensive disease of pregnancy with a worldwide incidence of 5-8%. This review focuses on recent developments in pre-eclampsia research related to angiogenesis and metabolism. We first address the 'angiogenic imbalance' theory, which hypothesizes that pre-eclampsia results from an imbalance of factors that promote or antagonize angiogenesis, such as soluble fms-like tyrosine kinase (sFlt1), 2-methoxyestradiol (2-ME) and catechol-O-methyltransferase (COMT). Next, we analyze the association between pre-eclampsia and dysfunctional metabolism of both homocysteine and placental glycogen. We hope that illuminating some of the various connections existing between angiogenesis and metabolism in pre-eclampsia will facilitate the update or reconsideration of old models of pathogenesis.
AB - Pre-eclampsia is a hypertensive disease of pregnancy with a worldwide incidence of 5-8%. This review focuses on recent developments in pre-eclampsia research related to angiogenesis and metabolism. We first address the 'angiogenic imbalance' theory, which hypothesizes that pre-eclampsia results from an imbalance of factors that promote or antagonize angiogenesis, such as soluble fms-like tyrosine kinase (sFlt1), 2-methoxyestradiol (2-ME) and catechol-O-methyltransferase (COMT). Next, we analyze the association between pre-eclampsia and dysfunctional metabolism of both homocysteine and placental glycogen. We hope that illuminating some of the various connections existing between angiogenesis and metabolism in pre-eclampsia will facilitate the update or reconsideration of old models of pathogenesis.
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U2 - 10.1016/j.tem.2010.05.002
DO - 10.1016/j.tem.2010.05.002
M3 - Review article
C2 - 20646932
AN - SCOPUS:77956189001
SN - 1043-2760
VL - 21
SP - 529
EP - 536
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 9
ER -