Abstract
The clinical use of protons for the treatment of cancer is one of the most technologically advanced forms of therapy. The newly commissioned M.D. Anderson Cancer Center, Proton Therapy Center Houston is one of the newest facilities offering a complete range of advanced proton therapies designed specifically to minimize treatment-related normal tissue toxicity. As an integral part of the clinical commissioning of this proton beam, we performed an in vivo assessment of the relative biologic effectiveness of the 250-MeV protons relative to standard cobalt60 using the jejunal crypt microcolony assay in mice. Our data are consistent with a generic relative biologic effectiveness of 1.1, and this relative biologic effectiveness is in agreement with that used to describe most other clinical proton therapy beams worldwide.
Original language | English (US) |
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Pages (from-to) | 968-970 |
Number of pages | 3 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 68 |
Issue number | 4 |
DOIs | |
State | Published - Jul 15 2007 |
Keywords
- Jejunum
- Proton
- RBE
- Relative biologic effectiveness
ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research