Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio; Saskia Reibe; Shabnam Shalapour; Geraldine J. Ooi; Matthew J. Watt; Michael Karin

doi:10.1016/j.cmet.2018.10.012

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio, Saskia Reibe, Shabnam Shalapour, Geraldine J. Ooi, Matthew J. Watt, Michael Karin

Research output: Contribution to journal › Review article › peer-review

160 Scopus citations

Abstract

Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

Original language	English (US)
Pages (from-to)	18-26
Number of pages	9
Journal	Cell Metabolism
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2018.10.012
State	Published - Jan 8 2019
Externally published	Yes

Keywords

RNA-seq
fatty liver
hepatocellular carcinoma
mouse models
non-alcoholic steatohepatitis
obesity

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2018.10.012

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title = "Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?",

abstract = "Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.",

keywords = "RNA-seq, fatty liver, hepatocellular carcinoma, mouse models, non-alcoholic steatohepatitis, obesity",

author = "Febbraio, {Mark A.} and Saskia Reibe and Shabnam Shalapour and Ooi, {Geraldine J.} and Watt, {Matthew J.} and Michael Karin",

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year = "2019",

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doi = "10.1016/j.cmet.2018.10.012",

language = "English (US)",

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T1 - Preclinical Models for Studying NASH-Driven HCC

T2 - How Useful Are They?

AU - Febbraio, Mark A.

AU - Reibe, Saskia

AU - Shalapour, Shabnam

AU - Ooi, Geraldine J.

AU - Watt, Matthew J.

AU - Karin, Michael

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

AB - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

KW - RNA-seq

KW - fatty liver

KW - hepatocellular carcinoma

KW - mouse models

KW - non-alcoholic steatohepatitis

KW - obesity

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DO - 10.1016/j.cmet.2018.10.012

M3 - Review article

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JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Abstract

Keywords

ASJC Scopus subject areas

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