Predicting suicidality in late-life depression by 3D convolutional neural network and cross-sample entropy analysis of resting-state fMRI

Chemin Lin, Chih Mao Huang, Wei Chang, You Xun Chang, Ho Ling Liu, Shu Hang Ng, Huang Li Lin, Tatia Mei Chun Lee, Shwu Hua Lee, Shun Chi Wu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Predicting suicide is a pressing issue among older adults; however, predicting its risk is difficult. Capitalizing on the recent development of machine learning, considerable progress has been made in predicting complex behavior such as suicide. As depression remained the strongest risk for suicide, we aimed to apply deep learning algorithms to identify suicidality in a group with late-life depression (LLD). Methods: We enrolled 83 patients with LLD, 35 of which were non-suicidal and 48 were suicidal, including 26 with only suicidal ideation and 22 with past suicide attempts, for resting-state functional magnetic resonance imaging (MRI). Cross-sample entropy (CSE) analysis was conducted to examine the complexity of MRI signals among brain regions. Three-dimensional (3D) convolutional neural networks (CNNs) were used, and the classification accuracy in each brain region was averaged to predict suicidality after sixfold cross-validation. Results: We found brain regions with a mean accuracy above 75% to predict suicidality located mostly in default mode, fronto-parietal, and cingulo-opercular resting-state networks. The models with right amygdala and left caudate provided the most reliable accuracy in all cross-validation folds, indicating their neurobiological importance in late-life suicide. Conclusion: Combining CSE analysis and the 3D CNN, several brain regions were found to be associated with suicidality.

Original languageEnglish (US)
Article numbere3348
JournalBrain and Behavior
Volume14
Issue number1
DOIs
StatePublished - Jan 2024

Keywords

  • convolutional neural network
  • cross-sample entropy
  • machine learning
  • older adult
  • resting-state fMRI
  • suicide
  • suicide attempt

ASJC Scopus subject areas

  • Behavioral Neuroscience

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