TY - JOUR
T1 - Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds
AU - Chen, Gang
AU - Wang, Feng
AU - Trachootham, Dunyaporn
AU - Huang, Peng
N1 - Funding Information:
Preparation of this work was supported in part by grants CA085563 , CA100428 , and CA109041 from the National Institutes of Health .
PY - 2010/11
Y1 - 2010/11
N2 - Mitochondria play essential roles in cellular metabolism, redox homeostasis, and regulation of cell death. Emerging evidences suggest that cancer cells exhibit various degrees of mitochondrial dysfunctions and metabolic alterations, which may serve as a basis to develop therapeutic strategies to preferentially kill the malignant cells. Mitochondria as a therapeutic target for cancer treatment is gaining much attention in the recent years, and agents that impact mitochondria with anticancer activity have been identified and tested in vitro and in vivo using various experimental systems. Anticancer agents that directly target mitochondria or indirectly affect mitochondrial functions are collectively classified as mitocans. This review article focuses on several natural compounds that preferentially kill cancer cells with mitochondrial dysfunction, and discusses the possible underlying mechanisms and their therapeutic implications in cancer treatment. Mitocans that have been comprehensively reviewed recently are not included in this article. Important issues such as therapeutic selectivity and the relevant biochemical basis are discussed in the context of future perspectives.
AB - Mitochondria play essential roles in cellular metabolism, redox homeostasis, and regulation of cell death. Emerging evidences suggest that cancer cells exhibit various degrees of mitochondrial dysfunctions and metabolic alterations, which may serve as a basis to develop therapeutic strategies to preferentially kill the malignant cells. Mitochondria as a therapeutic target for cancer treatment is gaining much attention in the recent years, and agents that impact mitochondria with anticancer activity have been identified and tested in vitro and in vivo using various experimental systems. Anticancer agents that directly target mitochondria or indirectly affect mitochondrial functions are collectively classified as mitocans. This review article focuses on several natural compounds that preferentially kill cancer cells with mitochondrial dysfunction, and discusses the possible underlying mechanisms and their therapeutic implications in cancer treatment. Mitocans that have been comprehensively reviewed recently are not included in this article. Important issues such as therapeutic selectivity and the relevant biochemical basis are discussed in the context of future perspectives.
KW - 2-Phenethyl isothiocyanate
KW - Apoptosis
KW - Energy metabolism
KW - Honokiol
KW - Mitochondrial dysfunction
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=78149360700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78149360700&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2010.08.001
DO - 10.1016/j.mito.2010.08.001
M3 - Review article
C2 - 20713185
AN - SCOPUS:78149360700
SN - 1567-7249
VL - 10
SP - 614
EP - 625
JO - Mitochondrion
JF - Mitochondrion
IS - 6
ER -