TY - JOUR
T1 - Premature ovarian failure and its consequences
T2 - Vasomotor symptoms, sexuality, and fertility
AU - Schover, Leslie R.
PY - 2008/2/2
Y1 - 2008/2/2
N2 - Premature ovarian failure is a common consequence of systemic treatment for premenopausal breast cancer. Vasomotor symptoms and sexual dysfunction occur frequently in women who have an abrupt menopause from chemotherapy or ovarian suppression. However, current fertility may be impaired even in women who are menstruating after chemotherapy, and survivors are at high risk for permanent ovarian failure at a young age. Hot flashes can be managed with venlaxafine, gabapentin, or - potentially - stress management. Providing advice on treating vaginal dryness and brief sexual counseling can often alleviate sexual dysfunction. Options for fertility preservation remain limited but are improving rapidly. Distress about interrupted childbearing has a long-term impact on the quality of life.
AB - Premature ovarian failure is a common consequence of systemic treatment for premenopausal breast cancer. Vasomotor symptoms and sexual dysfunction occur frequently in women who have an abrupt menopause from chemotherapy or ovarian suppression. However, current fertility may be impaired even in women who are menstruating after chemotherapy, and survivors are at high risk for permanent ovarian failure at a young age. Hot flashes can be managed with venlaxafine, gabapentin, or - potentially - stress management. Providing advice on treating vaginal dryness and brief sexual counseling can often alleviate sexual dysfunction. Options for fertility preservation remain limited but are improving rapidly. Distress about interrupted childbearing has a long-term impact on the quality of life.
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U2 - 10.1200/JCO.2007.14.1655
DO - 10.1200/JCO.2007.14.1655
M3 - Review article
C2 - 18258983
AN - SCOPUS:39149131745
SN - 0732-183X
VL - 26
SP - 753
EP - 758
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 5
ER -