Presence of messenger specifying sequences in the DNA of chromatin subunits

M. T. Kuo, C. G. Sahasrabuddhe, G. F. Saunders

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Messenger specifying sequences in subunits of human lymphocyte chromatin were detected by hybridization of DNA complementary to cytoplasmic polyadenylylated RNA with DNA isolated from the subunits. Comparison of the kinetics and extents of hybridization of complementary DNA with chromatin subunit DNA and with nuclear DNA showed that most of the repetitive sequences and single copy sequences in mRNA are present in chromatin subunits. This result indicates that inclusion of a DNA sequence into the subunit does not prevent its transcription in vivo.

Original languageEnglish (US)
Pages (from-to)1572-1575
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number5
DOIs
StatePublished - 1976

ASJC Scopus subject areas

  • General

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