TY - JOUR
T1 - Primary cutaneous adenoid cystic carcinoma a clinicopathologic and immunohistochemical study of 27 cases
AU - Ramakrishnan, Rathi
AU - Chaudhry, Iskander H.
AU - Ramdial, Pratistadevi
AU - Lazar, Alexander J.
AU - McMenamin, Mairin E.
AU - Kazakov, Dmitry
AU - Brenn, Thomas
AU - Calonje, Eduardo
PY - 2013/10
Y1 - 2013/10
N2 - Aims: This study examines clinical and pathologic features of primary cutaneous adenoid cystic carcinoma (ACC), with emphasis on biological behavior of these tumors. A total of 27 cases of primary cutaneous ACC with detailed follow-up information were evaluated. Clinically, these were solitary, slowgrowing lesions, half of which were in the head and neck area. The median age was 62 years with a male predilection. Surgical excision was the treatment of choice. Histologically, the lesions were similar to those seen in the salivary glands. Tumors were classified as grade 1 (17), grade 2 (3), and grade 3 (7). The mitotic count was generally low (mean=1.9/mm2), except in 2 high-grade tumors (>10 mitotic figures/mm2). Sixteen cases showed perineural invasion. Immunohistochemically, cytokeratin positivity was noted in 13/13 cases, and CD117 was observed in 10/10 cases, with luminal/cytoplasmic staining for epithelial membrane antigen (14/16) and at least focal luminal expression for carcinoembryonic antigen (11/16), smooth muscle actin (10/13), and S100 staining (9/13). Eighteen cases had follow- up data (median 54 mo), 9 of which had local recurrences (50%). Three cases showed metastatic disease. No statistical difference was noted between tumor grade and local recurrence (P=0.77). Primary cutaneous ACC is a distinct entity with a more indolent behavior compared with its salivary counterpart. The cutaneous lesions tend to recur locally but have a low metastatic potential.
AB - Aims: This study examines clinical and pathologic features of primary cutaneous adenoid cystic carcinoma (ACC), with emphasis on biological behavior of these tumors. A total of 27 cases of primary cutaneous ACC with detailed follow-up information were evaluated. Clinically, these were solitary, slowgrowing lesions, half of which were in the head and neck area. The median age was 62 years with a male predilection. Surgical excision was the treatment of choice. Histologically, the lesions were similar to those seen in the salivary glands. Tumors were classified as grade 1 (17), grade 2 (3), and grade 3 (7). The mitotic count was generally low (mean=1.9/mm2), except in 2 high-grade tumors (>10 mitotic figures/mm2). Sixteen cases showed perineural invasion. Immunohistochemically, cytokeratin positivity was noted in 13/13 cases, and CD117 was observed in 10/10 cases, with luminal/cytoplasmic staining for epithelial membrane antigen (14/16) and at least focal luminal expression for carcinoembryonic antigen (11/16), smooth muscle actin (10/13), and S100 staining (9/13). Eighteen cases had follow- up data (median 54 mo), 9 of which had local recurrences (50%). Three cases showed metastatic disease. No statistical difference was noted between tumor grade and local recurrence (P=0.77). Primary cutaneous ACC is a distinct entity with a more indolent behavior compared with its salivary counterpart. The cutaneous lesions tend to recur locally but have a low metastatic potential.
KW - Adnexal tumors
KW - Bartholin gland tumor
KW - Cutaneous adenoid cystic carcinoma
KW - Sweat duct carcinoma
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U2 - 10.1097/PAS.0b013e318299fcac
DO - 10.1097/PAS.0b013e318299fcac
M3 - Article
C2 - 24025525
AN - SCOPUS:84884529088
SN - 0147-5185
VL - 37
SP - 1603
EP - 1611
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 10
ER -