TY - JOUR
T1 - Primary Cutaneous Gamma-Delta (γ/δ) T-cell Lymphoma
T2 - An Unusual Case with Very Subtle Histopathological Findings
AU - Ramani, Nisha S.
AU - Curry, Jonathan L.
AU - Merrill, E. Dean
AU - Aung, Phyu P.
AU - Prieto, Victor
AU - Tetzlaff, Michael T.
AU - Duvic, Madeleine
AU - Miranda, Roberto
AU - Torres-Cabala, Carlos
N1 - Publisher Copyright:
© Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Primary cutaneous γ/δ T-cell lymphoma (PCGDTCL) accounts for <1% of all primary cutaneous lymphomas. These rare diseases are believed to originate from γ/δ lymphocytes. Clinical presentation may vary, but its clinical behavior is regarded as aggressive and long-term survival is anecdotal. This study describes the case of a 60-year-old man with multiple, rapidly progressing skin plaques on his head, arms, torso, buttocks, and legs. The histopathological changes seen in the skin biopsy were extraordinarily subtle with mild epidermal hyperplasia and a very sparse lymphoid infiltrate involving epidermis and superficial dermis. Immunohistochemical studies revealed the atypical intraepidermal hyperchromatic cells to be mostly positive for CD3 and CD7 and negative for both CD4 and CD8. The intraepidermal atypical lymphocytes were positive for TCR gamma, and negative for betaF1 and CD56. The clinical, morphologic, and immunohistochemical findings supported the diagnosis of PCGDTCL. This case illustrates a case of epidermotropic variant of PCGDTCL that, albeit a bland histopathological presentation, was associated with an aggressive clinical behavior.
AB - Primary cutaneous γ/δ T-cell lymphoma (PCGDTCL) accounts for <1% of all primary cutaneous lymphomas. These rare diseases are believed to originate from γ/δ lymphocytes. Clinical presentation may vary, but its clinical behavior is regarded as aggressive and long-term survival is anecdotal. This study describes the case of a 60-year-old man with multiple, rapidly progressing skin plaques on his head, arms, torso, buttocks, and legs. The histopathological changes seen in the skin biopsy were extraordinarily subtle with mild epidermal hyperplasia and a very sparse lymphoid infiltrate involving epidermis and superficial dermis. Immunohistochemical studies revealed the atypical intraepidermal hyperchromatic cells to be mostly positive for CD3 and CD7 and negative for both CD4 and CD8. The intraepidermal atypical lymphocytes were positive for TCR gamma, and negative for betaF1 and CD56. The clinical, morphologic, and immunohistochemical findings supported the diagnosis of PCGDTCL. This case illustrates a case of epidermotropic variant of PCGDTCL that, albeit a bland histopathological presentation, was associated with an aggressive clinical behavior.
KW - cutaneous T-cell lymphoma
KW - epidermotropic
KW - histopathology
KW - γ/δ T cell
UR - http://www.scopus.com/inward/record.url?scp=84983085267&partnerID=8YFLogxK
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U2 - 10.1097/DAD.0000000000000608
DO - 10.1097/DAD.0000000000000608
M3 - Article
C2 - 27533072
AN - SCOPUS:84983085267
SN - 0193-1091
VL - 38
SP - e147-e149
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 10
ER -