TY - JOUR
T1 - Primary effusion lymphoma
AU - Caraway, Nancy P.
AU - Stewart, John
N1 - Funding Information:
Supported in part by a grant from the Ministry of Health , Rome, within the framework of the Progetto Integrato Oncologia–Advanced Molecular Diagnostics project grant RFPS-2006-2-342010.7 (A.C.) and by a grant from CRO Aviano National Cancer Institute for an intramural project “Infectious Agents and Tumors” (A.C.).
PY - 2006/3
Y1 - 2006/3
N2 - Primary effusion lymphoma (PEL) is a rare, aggressive lymphoma that involves 1 or more of the serous (pleural, peritoneal, and peritoneal) cavities without other tumor masses and is associated with the human herpesvirus 8 (HHV-8), often in the setting of immunodeficiency. PEL occurs predominantly in men with acquired immunodeficiency syndrome (AIDS) but can be seen in iatrogenically immunosuppressed transplant patients and elderly individuals. The effusions show a dispersed population of large pleomorphic cells with eccentrically located nuclei, 1 or more prominent nucleoli, a perinuclear pallor, and moderately abundant cytoplasm. Binucleated and multinucleated cells and mitotic figures are seen commonly. This lymphoma frequently has an indeterminate immunophenotype that is not clearly B cell or T cell in origin, but it is often positive for CD45, CD30, and epithelial membrane antigen. In addition to HHV-8 positivity, many patients also have seropositive results for HIV and Epstein-Barr virus. PEL usually exhibits a complex karyotype without a characteristic aberration. The differential diagnosis typically includes other high-grade lymphomas that occur in HIV-infected patients, immunosuppressed patients, and elderly individuals. The prognosis of this high-grade lymphoma is usually poor, with a survival of only a few months, even with chemotherapy.
AB - Primary effusion lymphoma (PEL) is a rare, aggressive lymphoma that involves 1 or more of the serous (pleural, peritoneal, and peritoneal) cavities without other tumor masses and is associated with the human herpesvirus 8 (HHV-8), often in the setting of immunodeficiency. PEL occurs predominantly in men with acquired immunodeficiency syndrome (AIDS) but can be seen in iatrogenically immunosuppressed transplant patients and elderly individuals. The effusions show a dispersed population of large pleomorphic cells with eccentrically located nuclei, 1 or more prominent nucleoli, a perinuclear pallor, and moderately abundant cytoplasm. Binucleated and multinucleated cells and mitotic figures are seen commonly. This lymphoma frequently has an indeterminate immunophenotype that is not clearly B cell or T cell in origin, but it is often positive for CD45, CD30, and epithelial membrane antigen. In addition to HHV-8 positivity, many patients also have seropositive results for HIV and Epstein-Barr virus. PEL usually exhibits a complex karyotype without a characteristic aberration. The differential diagnosis typically includes other high-grade lymphomas that occur in HIV-infected patients, immunosuppressed patients, and elderly individuals. The prognosis of this high-grade lymphoma is usually poor, with a survival of only a few months, even with chemotherapy.
KW - Cytology
KW - HHV-8
KW - Kaposi sarcoma associated herpesvirus (KSHV)
KW - Primary effusion lymphoma
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U2 - 10.1097/01.pcr.0000204639.79014.0b
DO - 10.1097/01.pcr.0000204639.79014.0b
M3 - Review article
AN - SCOPUS:33746630251
SN - 1082-9784
VL - 11
SP - 78
EP - 84
JO - Pathology Case Reviews
JF - Pathology Case Reviews
IS - 2
ER -