Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation

Malisha R. Johnson; Daniel Del Carpio-Jayo; Pei Lin; Sergio Giralt; Paolo Anderlini; Richard E. Champlin; Issa F. Khouri; Saroj Vadhan-Raj; L. Jeffrey Medeiros; Carlos E. Bueso-Ramos

doi:10.1016/j.anndiagpath.2005.12.011

Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation

Malisha R. Johnson, Daniel Del Carpio-Jayo, Pei Lin, Sergio Giralt, Paolo Anderlini, Richard E. Champlin, Issa F. Khouri, Saroj Vadhan-Raj, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos

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30 Scopus citations

Abstract

Plasma cell leukemia (PCL) is a neoplastic disorder of plasma cells of which there are 2 forms, primary PCL and secondary PCL, the latter occurring in patients with a history of plasma cell myeloma. We describe 4 patients with primary PCL. In all cases, the bone marrow aspirate smears and biopsy specimens demonstrated a diffuse infiltrate of atypical plasma cells that were difficult to classify using morphologic criteria alone. Immunophenotypic studies showed that each case was positive for plasma cell-associated antigens (cytoplasmic immunoglobin, CD38, or CD138) and negative for CD20. Of 4 cases, 3 had complex karyotypes, including the t(11;14)(q13;q32) or del(11)(q13). Despite chemotherapy and the use of novel therapeutic agents and stem cell transplantation, all 4 patients had short survival.

Original language	English (US)
Pages (from-to)	263-268
Number of pages	6
Journal	Annals of Diagnostic Pathology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/j.anndiagpath.2005.12.011
State	Published - Oct 2006

Keywords

Chemotherapy
Plasma cell leukemia
Stem cell transplantation

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.anndiagpath.2005.12.011

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Johnson, M. R., Del Carpio-Jayo, D., Lin, P., Giralt, S., Anderlini, P., Champlin, R. E., Khouri, I. F., Vadhan-Raj, S., Medeiros, L. J., & Bueso-Ramos, C. E. (2006). Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation. Annals of Diagnostic Pathology, 10(5), 263-268. https://doi.org/10.1016/j.anndiagpath.2005.12.011

Johnson, MR, Del Carpio-Jayo, D, Lin, P, Giralt, S, Anderlini, P, Champlin, RE , Khouri, IF, Vadhan-Raj, S, Medeiros, LJ & Bueso-Ramos, CE 2006, 'Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation', Annals of Diagnostic Pathology, vol. 10, no. 5, pp. 263-268. https://doi.org/10.1016/j.anndiagpath.2005.12.011

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title = "Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation",

abstract = "Plasma cell leukemia (PCL) is a neoplastic disorder of plasma cells of which there are 2 forms, primary PCL and secondary PCL, the latter occurring in patients with a history of plasma cell myeloma. We describe 4 patients with primary PCL. In all cases, the bone marrow aspirate smears and biopsy specimens demonstrated a diffuse infiltrate of atypical plasma cells that were difficult to classify using morphologic criteria alone. Immunophenotypic studies showed that each case was positive for plasma cell-associated antigens (cytoplasmic immunoglobin, CD38, or CD138) and negative for CD20. Of 4 cases, 3 had complex karyotypes, including the t(11;14)(q13;q32) or del(11)(q13). Despite chemotherapy and the use of novel therapeutic agents and stem cell transplantation, all 4 patients had short survival.",

keywords = "Chemotherapy, Plasma cell leukemia, Stem cell transplantation",

author = "Johnson, {Malisha R.} and {Del Carpio-Jayo}, Daniel and Pei Lin and Sergio Giralt and Paolo Anderlini and Champlin, {Richard E.} and Khouri, {Issa F.} and Saroj Vadhan-Raj and Medeiros, {L. Jeffrey} and Bueso-Ramos, {Carlos E.}",

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doi = "10.1016/j.anndiagpath.2005.12.011",

language = "English (US)",

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AU - Johnson, Malisha R.

AU - Del Carpio-Jayo, Daniel

AU - Lin, Pei

AU - Giralt, Sergio

AU - Anderlini, Paolo

AU - Champlin, Richard E.

AU - Khouri, Issa F.

AU - Vadhan-Raj, Saroj

AU - Medeiros, L. Jeffrey

AU - Bueso-Ramos, Carlos E.

PY - 2006/10

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N2 - Plasma cell leukemia (PCL) is a neoplastic disorder of plasma cells of which there are 2 forms, primary PCL and secondary PCL, the latter occurring in patients with a history of plasma cell myeloma. We describe 4 patients with primary PCL. In all cases, the bone marrow aspirate smears and biopsy specimens demonstrated a diffuse infiltrate of atypical plasma cells that were difficult to classify using morphologic criteria alone. Immunophenotypic studies showed that each case was positive for plasma cell-associated antigens (cytoplasmic immunoglobin, CD38, or CD138) and negative for CD20. Of 4 cases, 3 had complex karyotypes, including the t(11;14)(q13;q32) or del(11)(q13). Despite chemotherapy and the use of novel therapeutic agents and stem cell transplantation, all 4 patients had short survival.

AB - Plasma cell leukemia (PCL) is a neoplastic disorder of plasma cells of which there are 2 forms, primary PCL and secondary PCL, the latter occurring in patients with a history of plasma cell myeloma. We describe 4 patients with primary PCL. In all cases, the bone marrow aspirate smears and biopsy specimens demonstrated a diffuse infiltrate of atypical plasma cells that were difficult to classify using morphologic criteria alone. Immunophenotypic studies showed that each case was positive for plasma cell-associated antigens (cytoplasmic immunoglobin, CD38, or CD138) and negative for CD20. Of 4 cases, 3 had complex karyotypes, including the t(11;14)(q13;q32) or del(11)(q13). Despite chemotherapy and the use of novel therapeutic agents and stem cell transplantation, all 4 patients had short survival.

KW - Chemotherapy

KW - Plasma cell leukemia

KW - Stem cell transplantation

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Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation

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