Priming reduces the bone marrow toxicity of carboplatin

M. E. Gore; C. A. Hills; Z. H. Siddik; J. P. Sloane; A. R. Winkley; I. E. Smith; J. L. Millar

doi:10.1016/0277-5379(87)90422-6

Priming reduces the bone marrow toxicity of carboplatin

M. E. Gore, C. A. Hills, Z. H. Siddik, J. P. Sloane, A. R. Winkley, I. E. Smith, J. L. Millar

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A dose of 170 mg/kg of carboplatin is lethal in mice, death occurring through bone marrow failure. This lethality can be avoided by giving the animals 200 mg/kg cyclophosphamide 1 or 2 days before this dose of carboplatin. The improved normal tissue tolerance cannot be explained by altered pharmacokinetics of carboplatin. Increased survival appears to be associated with a more rapid regeneration of the haemopoietic stem cells. Tumour tissue is not protected in the same way and thus a therapeutic gain can be achieved using this protocol.

Original language	English (US)
Pages (from-to)	75-80
Number of pages	6
Journal	European Journal of Cancer and Clinical Oncology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/0277-5379(87)90422-6
State	Published - Jan 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology

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10.1016/0277-5379(87)90422-6

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title = "Priming reduces the bone marrow toxicity of carboplatin",

abstract = "A dose of 170 mg/kg of carboplatin is lethal in mice, death occurring through bone marrow failure. This lethality can be avoided by giving the animals 200 mg/kg cyclophosphamide 1 or 2 days before this dose of carboplatin. The improved normal tissue tolerance cannot be explained by altered pharmacokinetics of carboplatin. Increased survival appears to be associated with a more rapid regeneration of the haemopoietic stem cells. Tumour tissue is not protected in the same way and thus a therapeutic gain can be achieved using this protocol.",

author = "Gore, {M. E.} and Hills, {C. A.} and Siddik, {Z. H.} and Sloane, {J. P.} and Winkley, {A. R.} and Smith, {I. E.} and Millar, {J. L.}",

year = "1987",

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AU - Gore, M. E.

AU - Hills, C. A.

AU - Siddik, Z. H.

AU - Sloane, J. P.

AU - Winkley, A. R.

AU - Smith, I. E.

AU - Millar, J. L.

PY - 1987/1

Y1 - 1987/1

N2 - A dose of 170 mg/kg of carboplatin is lethal in mice, death occurring through bone marrow failure. This lethality can be avoided by giving the animals 200 mg/kg cyclophosphamide 1 or 2 days before this dose of carboplatin. The improved normal tissue tolerance cannot be explained by altered pharmacokinetics of carboplatin. Increased survival appears to be associated with a more rapid regeneration of the haemopoietic stem cells. Tumour tissue is not protected in the same way and thus a therapeutic gain can be achieved using this protocol.

AB - A dose of 170 mg/kg of carboplatin is lethal in mice, death occurring through bone marrow failure. This lethality can be avoided by giving the animals 200 mg/kg cyclophosphamide 1 or 2 days before this dose of carboplatin. The improved normal tissue tolerance cannot be explained by altered pharmacokinetics of carboplatin. Increased survival appears to be associated with a more rapid regeneration of the haemopoietic stem cells. Tumour tissue is not protected in the same way and thus a therapeutic gain can be achieved using this protocol.

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VL - 23

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EP - 80

JO - European Journal of Cancer and Clinical Oncology

JF - European Journal of Cancer and Clinical Oncology

IS - 1

ER -

Priming reduces the bone marrow toxicity of carboplatin

Abstract

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