TY - JOUR
T1 - Principles of microRNA involvement in human cancers
AU - Ling, Hui
AU - Zhang, Wei
AU - Calin, George A.
PY - 2011
Y1 - 2011
N2 - Naturally occurring microRNAs (miRNAs), small non-coding RNAs of 19 to 24 nucleotides (nt), are encoded in the genomes of invertebrates, vertebrates, and plants. miRNAs act as regulators of gene expression during development and differentiation at the transcriptional, posttranscriptional, and/or translational levels, although most target genes are still elusive. Many miRNAs are conserved in sequence between distantly related organisms, suggesting that these molecules participate in essential processes. In this review, we present principles related to the basic and translational research that has emerged in the last decade, a period that can be truly considered the "miRNA revolution" in molecular oncology. These principles include the regulation mechanism of miRNA expression, functions of miRNAs in cancers, diagnostic values and therapeutic potentials of miRNAs. Furthermore, we present a compendium of information about the main miRNAs that have been identified in the last several years as playing important roles in cancers. Also, we orient the reader to several additional reviews that may provide a deeper understanding of this new and exciting field of research.
AB - Naturally occurring microRNAs (miRNAs), small non-coding RNAs of 19 to 24 nucleotides (nt), are encoded in the genomes of invertebrates, vertebrates, and plants. miRNAs act as regulators of gene expression during development and differentiation at the transcriptional, posttranscriptional, and/or translational levels, although most target genes are still elusive. Many miRNAs are conserved in sequence between distantly related organisms, suggesting that these molecules participate in essential processes. In this review, we present principles related to the basic and translational research that has emerged in the last decade, a period that can be truly considered the "miRNA revolution" in molecular oncology. These principles include the regulation mechanism of miRNA expression, functions of miRNAs in cancers, diagnostic values and therapeutic potentials of miRNAs. Furthermore, we present a compendium of information about the main miRNAs that have been identified in the last several years as playing important roles in cancers. Also, we orient the reader to several additional reviews that may provide a deeper understanding of this new and exciting field of research.
KW - Biomarker
KW - Cancer
KW - MicroRNA
KW - Mutation
KW - Non-coding RNA
UR - http://www.scopus.com/inward/record.url?scp=80355135204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80355135204&partnerID=8YFLogxK
U2 - 10.5732/cjc.011.10243
DO - 10.5732/cjc.011.10243
M3 - Review article
C2 - 22035854
AN - SCOPUS:80355135204
SN - 1000-467X
VL - 30
SP - 739
EP - 748
JO - Chinese Journal of Cancer
JF - Chinese Journal of Cancer
IS - 11
ER -