Probing DNA by 2-OG-dependent dioxygenase

Chi Lin Tsai; John A. Tainer

doi:10.1016/j.cell.2013.12.002

Probing DNA by 2-OG-dependent dioxygenase

Chi Lin Tsai, John A. Tainer

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.

Original language	English (US)
Pages (from-to)	1448-1450
Number of pages	3
Journal	Cell
Volume	155
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2013.12.002
State	Published - Dec 19 2013
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2013.12.002

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title = "Probing DNA by 2-OG-dependent dioxygenase",

abstract = "TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.",

author = "Tsai, {Chi Lin} and Tainer, {John A.}",

note = "Funding Information: The authors{\textquoteright} efforts on DNA repair are supported, in part, by National Institutes of Health Structural Cell Biology of DNA Repair Machines Grants P01 CA092584 and R01 CA097209.",

year = "2013",

month = dec,

day = "19",

doi = "10.1016/j.cell.2013.12.002",

language = "English (US)",

volume = "155",

pages = "1448--1450",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "7",

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TY - JOUR

T1 - Probing DNA by 2-OG-dependent dioxygenase

AU - Tsai, Chi Lin

AU - Tainer, John A.

N1 - Funding Information: The authors’ efforts on DNA repair are supported, in part, by National Institutes of Health Structural Cell Biology of DNA Repair Machines Grants P01 CA092584 and R01 CA097209.

PY - 2013/12/19

Y1 - 2013/12/19

N2 - TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.

AB - TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.

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U2 - 10.1016/j.cell.2013.12.002

DO - 10.1016/j.cell.2013.12.002

M3 - Short survey

C2 - 24360270

AN - SCOPUS:84894577481

SN - 0092-8674

VL - 155

SP - 1448

EP - 1450

JO - Cell

JF - Cell

IS - 7

ER -

Probing DNA by 2-OG-dependent dioxygenase

Abstract

ASJC Scopus subject areas

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