TY - JOUR
T1 - Production, isolation, and shipment of clinically relevant quantities of astatine-211
T2 - A simple and efficient approach to increasing supply
AU - McIntosh, Lauren A.
AU - Burns, Jonathan D.
AU - Tereshatov, Evgeny E.
AU - Muzzioli, Riccardo
AU - Hagel, Kris
AU - Jinadu, Noimat A.
AU - McCann, Laura A.
AU - Picayo, Gabriela A.
AU - Pisaneschi, Federica
AU - Piwnica-Worms, David
AU - Schultz, Steven J.
AU - Tabacaru, Gabriel C.
AU - Abbott, Austin
AU - Green, Brooklyn
AU - Hankins, Travis
AU - Hannaman, Andrew
AU - Harvey, Bryan
AU - Lofton, Kylie
AU - Rider, Robert
AU - Sorensen, Maxwell
AU - Tabacaru, Alexandra
AU - Tobin, Zachary
AU - Yennello, Sherry J.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - The alpha emitter astatine-211 (211At) is a promising candidate for cancer treatment based on Targeted Alpha (α) Therapy (TAT). A small number of facilities, distributed across the United States, are capable of accelerating α-particle beams to produce 211 At. However, challenges remain regarding strategic methods for shipping 211 At in a form adaptable to advanced radiochemistry reactions and other uses of the radioisotope. Purpose: Our method allows shipment of 211 At in various quantities in a form convenient for further radiochemistry. Procedures: For this study, a 3-octanone impregnated Amberchrom CG300M resin bed in a column cartridge was used to separate 211 At from the bismuth matrix on site at the production accelerator (Texas A&M) in preparation for shipping. Aliquots of 6 M HNO3 containing up to ≈2.22 GBq of 211 At from the dissolved target were successfully loaded and retained on columns. Exempt packages (<370 MBq) were shipped to a destination radiochemistry facility, University of Texas MD Anderson Cancer Center, in the form of a convenient air-dried column. Type A packages have been shipped overnight to University of Alabama at Birmingham. Main findings: Air-dried column hold times of various lengths did not inhibit simple and efficient recovery of 211 At. Solution eluted from the column was sufficiently high in specific activity to successfully radiolabel a model compound, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1), with 211 At. The method to prepare and ship 211 At described in this manuscript has also been used to ship larger quantities of 211 At a greater distance to University of Alabama at Birmingham. Principal conclusions: The successful proof of this method paves the way for the distribution of 211 At from Texas A&M University to research institutions and clinical oncology centers in Texas and elsewhere. Use of this simple method at other facilities has the potential increase the overall availability of 211 At for preclinical and clinical studies.
AB - The alpha emitter astatine-211 (211At) is a promising candidate for cancer treatment based on Targeted Alpha (α) Therapy (TAT). A small number of facilities, distributed across the United States, are capable of accelerating α-particle beams to produce 211 At. However, challenges remain regarding strategic methods for shipping 211 At in a form adaptable to advanced radiochemistry reactions and other uses of the radioisotope. Purpose: Our method allows shipment of 211 At in various quantities in a form convenient for further radiochemistry. Procedures: For this study, a 3-octanone impregnated Amberchrom CG300M resin bed in a column cartridge was used to separate 211 At from the bismuth matrix on site at the production accelerator (Texas A&M) in preparation for shipping. Aliquots of 6 M HNO3 containing up to ≈2.22 GBq of 211 At from the dissolved target were successfully loaded and retained on columns. Exempt packages (<370 MBq) were shipped to a destination radiochemistry facility, University of Texas MD Anderson Cancer Center, in the form of a convenient air-dried column. Type A packages have been shipped overnight to University of Alabama at Birmingham. Main findings: Air-dried column hold times of various lengths did not inhibit simple and efficient recovery of 211 At. Solution eluted from the column was sufficiently high in specific activity to successfully radiolabel a model compound, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1), with 211 At. The method to prepare and ship 211 At described in this manuscript has also been used to ship larger quantities of 211 At a greater distance to University of Alabama at Birmingham. Principal conclusions: The successful proof of this method paves the way for the distribution of 211 At from Texas A&M University to research institutions and clinical oncology centers in Texas and elsewhere. Use of this simple method at other facilities has the potential increase the overall availability of 211 At for preclinical and clinical studies.
KW - Astatine-211
KW - Radioisotope transport
KW - Separations chemistry
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U2 - 10.1016/j.nucmedbio.2023.108387
DO - 10.1016/j.nucmedbio.2023.108387
M3 - Article
C2 - 37837782
AN - SCOPUS:85173867233
SN - 0969-8051
VL - 126-127
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
M1 - 108387
ER -