TY - JOUR
T1 - Prognosis of surgically determined complete responders in advanced ovarian cancer
AU - Gershenson, David M.
AU - Copeland, Larry J.
AU - Wharton, Taylor
AU - Atkinson, E. Neely
AU - Sneige, Nour
AU - Edwards, Creighton L.
AU - Rutledge, Felix N.
PY - 1985/3/1
Y1 - 1985/3/1
N2 - From January 1971 through through December 1981, 246 patients with advanced (Stages III and IV) epithelial ovarian cancer underwent second‐look laparotomy at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston. Eighty‐five of these patients had a complete response (negative second‐look laparotomy) following treatment with a variety of chemotherapeutic regimens. Three patients had also received irradiation. Patients were analyzed according to pretreatment characteristics (age, FIGO stage, ascites, pleural effusion, histologic grade, tumor type, type of surgery, residual tumor diameter, initial clinical status) and by the number of biopsy specimens taken at second‐look laparotomy. The probability of recurrence and the length of survival following a negative second‐look laparotomy are statistically related to these characteristics. Twenty of the 85 patients (24%) developed recurrent disease 5 to 32 months after laparotomy. The estimated 2‐ and 5‐year survival rates are 99% and 85%, respectively. Patients who achieve a surgically determined complete response have an excellent chance for long‐term survival.
AB - From January 1971 through through December 1981, 246 patients with advanced (Stages III and IV) epithelial ovarian cancer underwent second‐look laparotomy at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston. Eighty‐five of these patients had a complete response (negative second‐look laparotomy) following treatment with a variety of chemotherapeutic regimens. Three patients had also received irradiation. Patients were analyzed according to pretreatment characteristics (age, FIGO stage, ascites, pleural effusion, histologic grade, tumor type, type of surgery, residual tumor diameter, initial clinical status) and by the number of biopsy specimens taken at second‐look laparotomy. The probability of recurrence and the length of survival following a negative second‐look laparotomy are statistically related to these characteristics. Twenty of the 85 patients (24%) developed recurrent disease 5 to 32 months after laparotomy. The estimated 2‐ and 5‐year survival rates are 99% and 85%, respectively. Patients who achieve a surgically determined complete response have an excellent chance for long‐term survival.
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U2 - 10.1002/1097-0142(19850301)55:5<1129::AID-CNCR2820550531>3.0.CO;2-O
DO - 10.1002/1097-0142(19850301)55:5<1129::AID-CNCR2820550531>3.0.CO;2-O
M3 - Article
C2 - 3155643
AN - SCOPUS:0021909401
SN - 0008-543X
VL - 55
SP - 1129
EP - 1135
JO - Cancer
JF - Cancer
IS - 5
ER -