Abstract
In contrast to early breast cancer, the prognostic effect of tumour angiogenesis in tumours with advanced axillary spread has been less studied. We retrospectively analysed the effect of microvessel density (MVD) and vascular endothelial growth factor (VEGF) by immunohistochemistry on the outcome of 215 patients treated uniformly within prospective trials of high-dose chemotherapy for 4-9 and ≥10 positive nodes, and followed for a median of 9 (range 3-13) years. Microvessel density was associated with epidermal growth factor receptor (EGFR) expression (P<0.001) and tumour size (P=0.001). Vascular endothelial growth factor overexpression (51% of patients) was associated with overexpression of EGFR (P=0.01) and HER2 (P<0.05), but not with MVD (P=0.3). High MVD was associated with worse relapse-free survival (74 vs 44%, P<0.001) and overall survival (76 vs 44%, P<0.001). Vascular endothelial growth factor overexpression had no effect on outcome. Multivariate analyses showed a prognostic effect of MVD independently of other known prognostic factors in this patient population. In conclusion, tumour angiogenesis, expressed as MVD, is a major independent prognostic factor in breast cancer patients with extensive axillary involvement.
Original language | English (US) |
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Pages (from-to) | 391-397 |
Number of pages | 7 |
Journal | British journal of cancer |
Volume | 97 |
Issue number | 3 |
DOIs | |
State | Published - Jul 31 2007 |
Keywords
- Angiogenesis
- High-dose chemotherapy
- High-risk breast cancer
- Microvessel density
- Prognostic factor
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Oncology
- Cancer Research