Prognostic biological features in neck dissection specimens

Julia A. Woolgar; Asterios Triantafyllou; James S. Lewis; Jennifer Hunt; Michelle D. Williams; Robert P. Takes; Lester D.R. Thompson; Pieter J. Slootweg; Kenneth O. Devaney; Alfio Ferlito

doi:10.1007/s00405-012-2170-9

Prognostic biological features in neck dissection specimens

Julia A. Woolgar, Asterios Triantafyllou, James S. Lewis, Jennifer Hunt, Michelle D. Williams, Robert P. Takes, Lester D.R. Thompson, Pieter J. Slootweg, Kenneth O. Devaney, Alfio Ferlito

Pathology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.

Original language	English (US)
Pages (from-to)	1581-1592
Number of pages	12
Journal	European Archives of Oto-Rhino-Laryngology
Volume	270
Issue number	5
DOIs	https://doi.org/10.1007/s00405-012-2170-9
State	Published - May 2013

Keywords

Head and neck cancer
Histopathology
Metastasis
Molecular analysis
Prognosis

ASJC Scopus subject areas

Otorhinolaryngology

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10.1007/s00405-012-2170-9

Cite this

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title = "Prognostic biological features in neck dissection specimens",

abstract = "The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.",

keywords = "Head and neck cancer, Histopathology, Metastasis, Molecular analysis, Prognosis",

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T1 - Prognostic biological features in neck dissection specimens

AU - Woolgar, Julia A.

AU - Triantafyllou, Asterios

AU - Lewis, James S.

AU - Hunt, Jennifer

AU - Williams, Michelle D.

AU - Takes, Robert P.

AU - Thompson, Lester D.R.

AU - Slootweg, Pieter J.

AU - Devaney, Kenneth O.

AU - Ferlito, Alfio

PY - 2013/5

Y1 - 2013/5

N2 - The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.

AB - The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.

KW - Head and neck cancer

KW - Histopathology

KW - Metastasis

KW - Molecular analysis

KW - Prognosis

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Prognostic biological features in neck dissection specimens

Abstract

Keywords

ASJC Scopus subject areas

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