TY - JOUR
T1 - Prognostic Correlations and Response to Treatment in Advanced Metastatic Malignant Melanoma
AU - Einhorn, Lawrence H.
AU - Burgess, M. Andrew
AU - Vallejos, Carlos
AU - Bodey, Gerald P.
AU - Gutterman, Jordan
AU - Mavligit, Giora
AU - Hersh, Evan M.
AU - Luce, James K.
AU - Frei, Emil
AU - Freireich, Emil J.
AU - Gottlieb, Jeffrey A.
PY - 1974/8/1
Y1 - 1974/8/1
N2 - Four-hundred twenty-six patients with disseminated melanoma were analyzed, all of whom were treated with chemotherapy. There was a high correlation with hepatic metastases and elevated lactic dehydrogenase levels. Although there were frequent false-positive lactic dehydrogenase levels, normal lactic dehydrogenase levels were consistently associated with a normal liver. Central nervous system disease was a major cause of morbidity and mortality in metastatic melanoma. Eleven % of the patients in this study had evidence of central nervous system disease at onset. The only treatment that was proven to be effective in these patients was whole-brain radiotherapy with concomitant dexamethasone administration. There were certain areas of anatomical involvement that correlated with an improved survival. These were patients that had pulmonary metastases only (median survival, 10 months) and patients with disease limited to the skin and S.C. tissue (median survival), 11 months). The median survival for all patients was 4.7 months. The response rate to a variety of treatment regimens with 5-(3, 3-dimethyl-1-triazeno)imidazole-4-carboxamide was 18% (75 of 426) for all patients and 23% for evaluable patients only. There was an increased response to 5-(3, 3-dimethyl-l-triazeno)imidiazole-4-carboxamide for nonvisceral involvement (28%), compared with visceral involvement (13%). The addition of l, 3-bis[2-chloroethy 1-1-nitrosourea appeared to have an increased response rate for pulmonary and other visceral involvement, compared with 5-(3, 3-dimethyl-l-triazeno)imidazole-4-carboxamide alone.
AB - Four-hundred twenty-six patients with disseminated melanoma were analyzed, all of whom were treated with chemotherapy. There was a high correlation with hepatic metastases and elevated lactic dehydrogenase levels. Although there were frequent false-positive lactic dehydrogenase levels, normal lactic dehydrogenase levels were consistently associated with a normal liver. Central nervous system disease was a major cause of morbidity and mortality in metastatic melanoma. Eleven % of the patients in this study had evidence of central nervous system disease at onset. The only treatment that was proven to be effective in these patients was whole-brain radiotherapy with concomitant dexamethasone administration. There were certain areas of anatomical involvement that correlated with an improved survival. These were patients that had pulmonary metastases only (median survival, 10 months) and patients with disease limited to the skin and S.C. tissue (median survival), 11 months). The median survival for all patients was 4.7 months. The response rate to a variety of treatment regimens with 5-(3, 3-dimethyl-1-triazeno)imidazole-4-carboxamide was 18% (75 of 426) for all patients and 23% for evaluable patients only. There was an increased response to 5-(3, 3-dimethyl-l-triazeno)imidiazole-4-carboxamide for nonvisceral involvement (28%), compared with visceral involvement (13%). The addition of l, 3-bis[2-chloroethy 1-1-nitrosourea appeared to have an increased response rate for pulmonary and other visceral involvement, compared with 5-(3, 3-dimethyl-l-triazeno)imidazole-4-carboxamide alone.
UR - http://www.scopus.com/inward/record.url?scp=0016186530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016186530&partnerID=8YFLogxK
M3 - Article
C2 - 4842252
AN - SCOPUS:0016186530
SN - 0008-5472
VL - 34
SP - 1995
EP - 2004
JO - Cancer Research
JF - Cancer Research
IS - 8
ER -