TY - JOUR
T1 - Prognostic factors for surgically resected non-small cell lung cancer with cavity formation
AU - Shigefuku, Shunsuke
AU - Kudo, Yujin
AU - Yunaiyama, Daisuke
AU - Matsubayashi, Jun
AU - Park, Jinho
AU - Nagao, Toshitaka
AU - Shimada, Yoshihisa
AU - Saji, Hisashi
AU - Hagiwara, Masaru
AU - Okano, Tetsuya
AU - Kakihana, Masatoshi
AU - Kajiwara, Naohiro
AU - Ohira, Tatsuo
AU - Ikeda, Norihiko
N1 - Publisher Copyright:
© 2018 Journal of Thoracic Disease.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Background: Small pulmonary nodules have been detected frequently by computed tomography (CT). Lung cancers with cavity formation are also easily detected. There are a few reports focused on the cavity wall, although cancer cells exist along the cavity wall, not inside. We evaluated the impact of cavity wall thickness on prognosis and assessed the clinicopathological features in non-small cell lung cancer (NSCLC) with cavity formation. Methods: Between 2005 and 2011, 1,313 patients underwent complete resection for NSCLC. Of these cases, we reviewed 65 patients (5.0%) diagnosed with NSCLC with cavity formation by chest CT. We classified the patients into three groups based on the maximum cavity wall thickness, namely, < 4 mm (Group 1, 8 patients), > 4 and < 15 mm (Group 2, 33 patients), and > 15 mm (Group 3, 24 patients). Results: The number of patients with pathological whole tumor size > 3 cm was 2 (25%) in Group 1, 17 (52%) in Group 2, and 23 (96%) in Group 3 (P < 0.001). Cases with lymph node metastasis were 0 (0%) in Group 1, 5 (15%) in Group 2, and 10 (42%) in Group 3 (P=0.016). The 5-year overall survival (OS) rates were 100% in Group 1, 84.0% in Group 2, and 52.0% in Group 3, with significant differences between Group 1 and Group 3 (P=0.044) and between Group 2 and Group 3 (P=0.034). In univariate analysis, neither whole tumor size nor lymph node metastasis was a prognostic factor for OS (P=0.51, P=0.27). Only cavity wall thickness was a significant prognostic factor by multivariate analysis (P=0.009). Conclusions: Maximum cavity wall thickness was an important prognostic factor in NSCLCs with cavity formation, comparable with other established prognostic factors.
AB - Background: Small pulmonary nodules have been detected frequently by computed tomography (CT). Lung cancers with cavity formation are also easily detected. There are a few reports focused on the cavity wall, although cancer cells exist along the cavity wall, not inside. We evaluated the impact of cavity wall thickness on prognosis and assessed the clinicopathological features in non-small cell lung cancer (NSCLC) with cavity formation. Methods: Between 2005 and 2011, 1,313 patients underwent complete resection for NSCLC. Of these cases, we reviewed 65 patients (5.0%) diagnosed with NSCLC with cavity formation by chest CT. We classified the patients into three groups based on the maximum cavity wall thickness, namely, < 4 mm (Group 1, 8 patients), > 4 and < 15 mm (Group 2, 33 patients), and > 15 mm (Group 3, 24 patients). Results: The number of patients with pathological whole tumor size > 3 cm was 2 (25%) in Group 1, 17 (52%) in Group 2, and 23 (96%) in Group 3 (P < 0.001). Cases with lymph node metastasis were 0 (0%) in Group 1, 5 (15%) in Group 2, and 10 (42%) in Group 3 (P=0.016). The 5-year overall survival (OS) rates were 100% in Group 1, 84.0% in Group 2, and 52.0% in Group 3, with significant differences between Group 1 and Group 3 (P=0.044) and between Group 2 and Group 3 (P=0.034). In univariate analysis, neither whole tumor size nor lymph node metastasis was a prognostic factor for OS (P=0.51, P=0.27). Only cavity wall thickness was a significant prognostic factor by multivariate analysis (P=0.009). Conclusions: Maximum cavity wall thickness was an important prognostic factor in NSCLCs with cavity formation, comparable with other established prognostic factors.
KW - Cavity
KW - Cavity wall thickness
KW - Non-small cell lung cancer (NSCLC)
KW - Prognostic factor
KW - Whole tumor size
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U2 - 10.21037/jtd.2018.01.61
DO - 10.21037/jtd.2018.01.61
M3 - Article
C2 - 29607170
AN - SCOPUS:85042116928
SN - 2072-1439
VL - 10
SP - 973
EP - 983
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
IS - 2
ER -