Prognostic factors for survival in malignant melanoma of the eyelid skin

Bita Esmaeli, Bao Wang, Michael Deavers, Ann Marie Gillenwater, Helmuth Goepfert, Eduardo M Diaz Jr, Susan Eicher

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Purpose: This study aimed to determine the prognostic factors for survival and disease-free interval for malignant melanoma of the eyelid skin. Methods: This was a retrospective, nonrandomized, clinical review. Twenty-four patients with eyelid skin melanoma were identified through a search of the tumor registry at M. D. Anderson Cancer Center. Patients were treated between 1953 and 1994. The follow-up ranged from 3 to 18 years (mean = 9.6 years). Primary treatment in all cases entailed wide local excision of the tumor. Patients in whom regional lymph node metastasis developed underwent parotidectomy or neck dissection, with or without adjuvant chemotherapy or external beam radiation. Descriptive statistics were used to characterize the patients. Survival analysis in terms of disease-free survival and recurrence-free survival was performed using age, sex, location of tumor (upper lid, lower lid, or both), histologic type of melanoma, Breslow thickness, and Clark's level as independent variables for survival. Results: Age, sex, location, and the histologic type of tumor were not significant prognostic indicators, for survival in this cohort. Clark's level ≥IV by itself was a statistically significant predictor of decreased survival. In addition, tumors with either Clark's level ≥IV or Breslow thickness ≥ 1.5 mm were associated with increased mortality. Conclusion: Clark's level ≥IV or Breslow thickness ≥1.5 mm are poor prognostic indicators for malignant melanomas of the eyelid skin. Clinicians should have a high level of suspicion for occult regional lymph node metastasis when treating patients with these tumor features.

Original languageEnglish (US)
Pages (from-to)250-257
Number of pages8
JournalOphthalmic Plastic and Reconstructive Surgery
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2000

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Eyelids
Melanoma
Skin
Survival
Neoplasms
Disease-Free Survival
Lymph Nodes
Neoplasm Metastasis
Neck Dissection
Adjuvant Chemotherapy
Survival Analysis
Registries
Radiation
Recurrence
Mortality

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Prognostic factors for survival in malignant melanoma of the eyelid skin. / Esmaeli, Bita; Wang, Bao; Deavers, Michael; Gillenwater, Ann Marie; Goepfert, Helmuth; Diaz Jr, Eduardo M; Eicher, Susan.

In: Ophthalmic Plastic and Reconstructive Surgery, Vol. 16, No. 4, 01.01.2000, p. 250-257.

Research output: Contribution to journalArticle

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abstract = "Purpose: This study aimed to determine the prognostic factors for survival and disease-free interval for malignant melanoma of the eyelid skin. Methods: This was a retrospective, nonrandomized, clinical review. Twenty-four patients with eyelid skin melanoma were identified through a search of the tumor registry at M. D. Anderson Cancer Center. Patients were treated between 1953 and 1994. The follow-up ranged from 3 to 18 years (mean = 9.6 years). Primary treatment in all cases entailed wide local excision of the tumor. Patients in whom regional lymph node metastasis developed underwent parotidectomy or neck dissection, with or without adjuvant chemotherapy or external beam radiation. Descriptive statistics were used to characterize the patients. Survival analysis in terms of disease-free survival and recurrence-free survival was performed using age, sex, location of tumor (upper lid, lower lid, or both), histologic type of melanoma, Breslow thickness, and Clark's level as independent variables for survival. Results: Age, sex, location, and the histologic type of tumor were not significant prognostic indicators, for survival in this cohort. Clark's level ≥IV by itself was a statistically significant predictor of decreased survival. In addition, tumors with either Clark's level ≥IV or Breslow thickness ≥ 1.5 mm were associated with increased mortality. Conclusion: Clark's level ≥IV or Breslow thickness ≥1.5 mm are poor prognostic indicators for malignant melanomas of the eyelid skin. Clinicians should have a high level of suspicion for occult regional lymph node metastasis when treating patients with these tumor features.",
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T1 - Prognostic factors for survival in malignant melanoma of the eyelid skin

AU - Esmaeli, Bita

AU - Wang, Bao

AU - Deavers, Michael

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AU - Diaz Jr, Eduardo M

AU - Eicher, Susan

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N2 - Purpose: This study aimed to determine the prognostic factors for survival and disease-free interval for malignant melanoma of the eyelid skin. Methods: This was a retrospective, nonrandomized, clinical review. Twenty-four patients with eyelid skin melanoma were identified through a search of the tumor registry at M. D. Anderson Cancer Center. Patients were treated between 1953 and 1994. The follow-up ranged from 3 to 18 years (mean = 9.6 years). Primary treatment in all cases entailed wide local excision of the tumor. Patients in whom regional lymph node metastasis developed underwent parotidectomy or neck dissection, with or without adjuvant chemotherapy or external beam radiation. Descriptive statistics were used to characterize the patients. Survival analysis in terms of disease-free survival and recurrence-free survival was performed using age, sex, location of tumor (upper lid, lower lid, or both), histologic type of melanoma, Breslow thickness, and Clark's level as independent variables for survival. Results: Age, sex, location, and the histologic type of tumor were not significant prognostic indicators, for survival in this cohort. Clark's level ≥IV by itself was a statistically significant predictor of decreased survival. In addition, tumors with either Clark's level ≥IV or Breslow thickness ≥ 1.5 mm were associated with increased mortality. Conclusion: Clark's level ≥IV or Breslow thickness ≥1.5 mm are poor prognostic indicators for malignant melanomas of the eyelid skin. Clinicians should have a high level of suspicion for occult regional lymph node metastasis when treating patients with these tumor features.

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