Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer

Ryoko Suzuki; Xiong Wei; Pamela K. Allen; James D. Cox; Ritsuko Komaki; Steven H. Lin

doi:10.1016/j.cllc.2018.11.013

Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer

Ryoko Suzuki, Xiong Wei, Pamela K. Allen, James D. Cox, Ritsuko Komaki, Steven H. Lin

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.

Original language	English (US)
Pages (from-to)	117-123
Number of pages	7
Journal	Clinical Lung Cancer
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.cllc.2018.11.013
State	Published - Mar 2019

Keywords

Chemoradiation
Lymphopenia
Neutrophil-to-lymphocyte ratio
Overall survival
Small cell lung cancer

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.1016/j.cllc.2018.11.013

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title = "Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer",

abstract = "We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.",

keywords = "Chemoradiation, Lymphopenia, Neutrophil-to-lymphocyte ratio, Overall survival, Small cell lung cancer",

author = "Ryoko Suzuki and Xiong Wei and Allen, {Pamela K.} and Cox, {James D.} and Ritsuko Komaki and Lin, {Steven H.}",

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year = "2019",

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doi = "10.1016/j.cllc.2018.11.013",

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AU - Wei, Xiong

AU - Allen, Pamela K.

AU - Cox, James D.

AU - Komaki, Ritsuko

AU - Lin, Steven H.

PY - 2019/3

Y1 - 2019/3

N2 - We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.

AB - We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.

KW - Chemoradiation

KW - Lymphopenia

KW - Neutrophil-to-lymphocyte ratio

KW - Overall survival

KW - Small cell lung cancer

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ER -

Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer

Abstract

Keywords

ASJC Scopus subject areas

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