TY - JOUR
T1 - Prognostic value of circulating tumor cells in ovarian cancer
T2 - A meta-analysis
AU - Zhou, Yunlan
AU - Bian, Bingxian
AU - Yuan, Xiangliang
AU - Xie, Guohua
AU - Ma, Yanhui
AU - Shen, Lisong
N1 - Publisher Copyright:
© 2015 Zhou et al.
PY - 2015/6/22
Y1 - 2015/6/22
N2 - Background The prognostic value of circulating tumor cells (CTCs) in ovarian cancer has been investigated in previous studies, but the results are controversial. Therefore we performed a metaanalysis to systematically review these data and evaluate the value of CTCs in ovarian cancer. Materials and Methods A literary search for relevant studies was performed on Embase, Medline and Web of Science databases. Then pooled hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, sensitivity analyses, meta-regression analyses and publication bias were conducted. Results This meta-analysis is based on 11 publications and comprises a total of 1129 patients. The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75). Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90). The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85). Conclusion Our study demonstrates that CTC status is associated with OS and PFS/DFS in ovarian cancer.
AB - Background The prognostic value of circulating tumor cells (CTCs) in ovarian cancer has been investigated in previous studies, but the results are controversial. Therefore we performed a metaanalysis to systematically review these data and evaluate the value of CTCs in ovarian cancer. Materials and Methods A literary search for relevant studies was performed on Embase, Medline and Web of Science databases. Then pooled hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, sensitivity analyses, meta-regression analyses and publication bias were conducted. Results This meta-analysis is based on 11 publications and comprises a total of 1129 patients. The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75). Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90). The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85). Conclusion Our study demonstrates that CTC status is associated with OS and PFS/DFS in ovarian cancer.
UR - http://www.scopus.com/inward/record.url?scp=84939201440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939201440&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0130873
DO - 10.1371/journal.pone.0130873
M3 - Article
C2 - 26098665
AN - SCOPUS:84939201440
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 6
M1 - e0130873
ER -