Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: A prospective analysis

F. Janot; J. Klijanienko; A. Russo; J. P. Mamet; F. De Braud; A. K. El-Naggar; J. P. Pignon; B. Luboinski; E. Cvitkovic

doi:10.1038/bjc.1996.92

Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: A prospective analysis

F. Janot, J. Klijanienko, A. Russo, J. P. Mamet, F. De Braud, A. K. El-Naggar, J. P. Pignon, B. Luboinski, E. Cvitkovic

Pathology, Anatomical

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation. tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.

Original language	English (US)
Pages (from-to)	531-538
Number of pages	8
Journal	British journal of cancer
Volume	73
Issue number	4
DOIs	https://doi.org/10.1038/bjc.1996.92
State	Published - 1996

Keywords

Grading
Head and neck cancer
Metastatic risk
Ploidy
Prognostic factors

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/bjc.1996.92

Cite this

@article{747bb2b57759439b92e94d0e89600aea,

title = "Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: A prospective analysis",

abstract = "The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation. tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.",

keywords = "Grading, Head and neck cancer, Metastatic risk, Ploidy, Prognostic factors",

author = "F. Janot and J. Klijanienko and A. Russo and Mamet, {J. P.} and {De Braud}, F. and El-Naggar, {A. K.} and Pignon, {J. P.} and B. Luboinski and E. Cvitkovic",

note = "Funding Information: This investigation was supported by grants from the Commission of the European Communities (Dr De Braud - EC grant 900167; Dr Russo- EC grant 900336) and Institut Curie (Dr Klijanienko). We are grateful to Drs JM Richard, G Schwaab, P Marandas, AM Leridant, G Mamelle and M Julieron for the surgical specimens, to Dr J-P Armand for helpful advice, to Dr C Micheau for pathological assistance, to Mrs G Terroni for her assistance in the study, to Mrs L Saint-Ange for revising the manuscript and to D Bert for its typing and preparation.",

year = "1996",

doi = "10.1038/bjc.1996.92",

language = "English (US)",

volume = "73",

pages = "531--538",

journal = "British journal of cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma

T2 - A prospective analysis

AU - Janot, F.

AU - Klijanienko, J.

AU - Russo, A.

AU - Mamet, J. P.

AU - De Braud, F.

AU - El-Naggar, A. K.

AU - Pignon, J. P.

AU - Luboinski, B.

AU - Cvitkovic, E.

N1 - Funding Information: This investigation was supported by grants from the Commission of the European Communities (Dr De Braud - EC grant 900167; Dr Russo- EC grant 900336) and Institut Curie (Dr Klijanienko). We are grateful to Drs JM Richard, G Schwaab, P Marandas, AM Leridant, G Mamelle and M Julieron for the surgical specimens, to Dr J-P Armand for helpful advice, to Dr C Micheau for pathological assistance, to Mrs G Terroni for her assistance in the study, to Mrs L Saint-Ange for revising the manuscript and to D Bert for its typing and preparation.

PY - 1996

Y1 - 1996

N2 - The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation. tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.

AB - The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation. tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.

KW - Grading

KW - Head and neck cancer

KW - Metastatic risk

KW - Ploidy

KW - Prognostic factors

UR - http://www.scopus.com/inward/record.url?scp=0030038184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030038184&partnerID=8YFLogxK

U2 - 10.1038/bjc.1996.92

DO - 10.1038/bjc.1996.92

M3 - Article

C2 - 8595170

AN - SCOPUS:0030038184

SN - 0007-0920

VL - 73

SP - 531

EP - 538

JO - British journal of cancer

JF - British journal of cancer

IS - 4

ER -

Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: A prospective analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this