Prognostic value of nodal ratios in node-positive breast cancer: A compiled update

Vincent Vinh-Hung; Nam P. Nguyen; Gábor Cserni; Pauline Truong; Wendy Woodward; Helena M. Verkooijen; Donald Promish; Naoto T. Ueno; Patricia Tai; Yago Nieto; Sue Joseph; Wolfgang Janni; Frank Vicini; Melanie Royce; Guy Storme; Anne Marie Wallace; Georges Vlastos; Christine Bouchardy; Gabriel N. Hortobagyi

doi:10.2217/fon.09.129

Prognostic value of nodal ratios in node-positive breast cancer: A compiled update

Vincent Vinh-Hung, Nam P. Nguyen, Gábor Cserni, Pauline Truong, Wendy Woodward, Helena M. Verkooijen, Donald Promish, Naoto T. Ueno, Patricia Tai, Yago Nieto, Sue Joseph, Wolfgang Janni, Frank Vicini, Melanie Royce, Guy Storme, Anne Marie Wallace, Georges Vlastos, Christine Bouchardy, Gabriel N. Hortobagyi

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

The number of positive axillary nodes is a strong prognostic factor in breast cancer, but is affected by variability in nodal staging technique yielding varying numbers of excised nodes. The nodal ratio of positive to excised nodes is an alternative that could address this variability. Our 2006 review found that the nodal ratio consistently outperformed the number of positive nodes, providing strong arguments for the use of nodal ratios in breast cancer staging and management. New evidence has continued to accrue confirming the prognostic significance of nodal ratios in various worldwide population settings. This review provides an updated summary of available data, and discusses the potential application of the nodal ratio to breast cancer staging and prognostication, its role in the context of modern surgical techniques such as sentinel node biopsy, and its potential correlations with new biologic markers such as circulating tumor cells and breast cancer stem cells.

Original language	English (US)
Pages (from-to)	1585-1603
Number of pages	19
Journal	Future Oncology
Volume	5
Issue number	10
DOIs	https://doi.org/10.2217/fon.09.129
State	Published - 2009

Keywords

Breast cancer
Comparability
INRWG
International Nodal Ratio Working Group
Lymph node
Overdispersion
Staging

ASJC Scopus subject areas

Oncology
Cancer Research

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10.2217/fon.09.129

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Vinh-Hung, V., Nguyen, N. P., Cserni, G., Truong, P., Woodward, W., Verkooijen, H. M., Promish, D., Ueno, N. T., Tai, P., Nieto, Y., Joseph, S., Janni, W., Vicini, F., Royce, M., Storme, G., Wallace, A. M., Vlastos, G., Bouchardy, C., & Hortobagyi, G. N. (2009). Prognostic value of nodal ratios in node-positive breast cancer: A compiled update. Future Oncology, 5(10), 1585-1603. https://doi.org/10.2217/fon.09.129

Vinh-Hung, V, Nguyen, NP, Cserni, G, Truong, P, Woodward, W, Verkooijen, HM, Promish, D, Ueno, NT, Tai, P, Nieto, Y, Joseph, S, Janni, W, Vicini, F, Royce, M, Storme, G, Wallace, AM, Vlastos, G, Bouchardy, C & Hortobagyi, GN 2009, 'Prognostic value of nodal ratios in node-positive breast cancer: A compiled update', Future Oncology, vol. 5, no. 10, pp. 1585-1603. https://doi.org/10.2217/fon.09.129

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title = "Prognostic value of nodal ratios in node-positive breast cancer: A compiled update",

abstract = "The number of positive axillary nodes is a strong prognostic factor in breast cancer, but is affected by variability in nodal staging technique yielding varying numbers of excised nodes. The nodal ratio of positive to excised nodes is an alternative that could address this variability. Our 2006 review found that the nodal ratio consistently outperformed the number of positive nodes, providing strong arguments for the use of nodal ratios in breast cancer staging and management. New evidence has continued to accrue confirming the prognostic significance of nodal ratios in various worldwide population settings. This review provides an updated summary of available data, and discusses the potential application of the nodal ratio to breast cancer staging and prognostication, its role in the context of modern surgical techniques such as sentinel node biopsy, and its potential correlations with new biologic markers such as circulating tumor cells and breast cancer stem cells.",

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author = "Vincent Vinh-Hung and Nguyen, {Nam P.} and G{\'a}bor Cserni and Pauline Truong and Wendy Woodward and Verkooijen, {Helena M.} and Donald Promish and Ueno, {Naoto T.} and Patricia Tai and Yago Nieto and Sue Joseph and Wolfgang Janni and Frank Vicini and Melanie Royce and Guy Storme and Wallace, {Anne Marie} and Georges Vlastos and Christine Bouchardy and Hortobagyi, {Gabriel N.}",

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AU - Promish, Donald

AU - Ueno, Naoto T.

AU - Tai, Patricia

AU - Nieto, Yago

AU - Joseph, Sue

AU - Janni, Wolfgang

AU - Vicini, Frank

AU - Royce, Melanie

AU - Storme, Guy

AU - Wallace, Anne Marie

AU - Vlastos, Georges

AU - Bouchardy, Christine

AU - Hortobagyi, Gabriel N.

PY - 2009

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KW - Breast cancer

KW - Comparability

KW - INRWG

KW - International Nodal Ratio Working Group

KW - Lymph node

KW - Overdispersion

KW - Staging

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Prognostic value of nodal ratios in node-positive breast cancer: A compiled update

Abstract

Keywords

ASJC Scopus subject areas

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