TY - JOUR
T1 - Progressive leukemic non-nodal mantle cell lymphoma associated with deletions of TP53, ATM, and/or 13q14
AU - Chapman-Fredricks, Jennifer
AU - Sandoval-Sus, Jose
AU - Vega, Francisco
AU - Lossos, Izidore S.
PY - 2014/8
Y1 - 2014/8
N2 - Leukemic, non-nodal mantle cell lymphoma (MCL) is a relatively indolent disease characterized by asymptomatic leukemic presentation, non-nodal disease distribution, and slow disease progression, particularly in comparison to that of classic nodal MCL. We studied 3 cases of leukemic, non-nodal MCL in which TP53, ATM, and/or 13q14 deletions were identified. All three patients had disease progression leading to treatment requirements in two of the patients at 5 and 18 months after initial diagnosis. The third patient also clinically progressed 25 months after initial diagnosis but was lost to follow up despite recommendation for initiation of therapy. We present these cases as potential evidence that while leukemic non-nodal MCL is typically an indolent disease compared to classically defined mantle cell lymphoma, cytogenetic heterogeneity exists and cases with TP53, ATM, and/or 13q14 deletions may have a relatively aggressive clinical course.
AB - Leukemic, non-nodal mantle cell lymphoma (MCL) is a relatively indolent disease characterized by asymptomatic leukemic presentation, non-nodal disease distribution, and slow disease progression, particularly in comparison to that of classic nodal MCL. We studied 3 cases of leukemic, non-nodal MCL in which TP53, ATM, and/or 13q14 deletions were identified. All three patients had disease progression leading to treatment requirements in two of the patients at 5 and 18 months after initial diagnosis. The third patient also clinically progressed 25 months after initial diagnosis but was lost to follow up despite recommendation for initiation of therapy. We present these cases as potential evidence that while leukemic non-nodal MCL is typically an indolent disease compared to classically defined mantle cell lymphoma, cytogenetic heterogeneity exists and cases with TP53, ATM, and/or 13q14 deletions may have a relatively aggressive clinical course.
KW - ATM deletion
KW - Leukemic mantle cell lymphoma
KW - Non-nodal mantle cell lymphoma
KW - TPp53 alteration
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U2 - 10.1016/j.anndiagpath.2014.03.006
DO - 10.1016/j.anndiagpath.2014.03.006
M3 - Article
C2 - 24852242
AN - SCOPUS:84904252308
SN - 1092-9134
VL - 18
SP - 214
EP - 219
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
IS - 4
ER -