Abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating infectious disease caused by the JC virus. It was originally described in patients with chronic lymphocytic leukemia (CLL). Richter's syndrome, or transformation to large cell lymphoma, occurs in approximately 3% of patients with CLL, and carries a poor prognosis. We report a patient with documented PML and concurrent Richter's transformation outside the central nervous system. Before establishing a definitive diagnosis of PML, radiation therapy to the presumed lymphomatous brain lesion had been considered, raising the issue of whether stereotactic brain biopsy should be considered in every patient in a similar situation. Although this is likely a rare occurrence, patients with Richter's transformation documented at an extra-neural site and a brain lesion may benefit from the establishment of an infectious diagnosis which would influence therapy.
Original language | English (US) |
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Pages (from-to) | 183-190 |
Number of pages | 8 |
Journal | Leukemia and Lymphoma |
Volume | 38 |
Issue number | 1-2 |
DOIs | |
State | Published - 2000 |
Keywords
- Chronic lymphocytic leukemia
- JC virus
- Large cell lymphoma
- Polyomavirus homins 2
- Progressive multifocal leukoencephalopathy
- Richter's syndrome
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research