Proliferating cell nuclear antigen: A new marker of proliferation in cancer

David R. Keim; Sam M. Hanash

doi:10.3109/10428199209053584

Proliferating cell nuclear antigen: A new marker of proliferation in cancer

David R. Keim, Sam M. Hanash

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Proliferating cell nuclear antigen (PCNA) is the auxiliary protein of DNA polymerase δ It is induced in late G₁ and S phases following mitotic stimulation of resting cells and is required for efficient DNA synthesis and cell cycle progression. Its expression in normal and malignant proliferating cells is related to proliferative activity. Because of the potential for substantial variability between proliferating cell populations with respect to the proportions of cells in G0 or G1, assays of PCNA can complement DNA analysis for assessment of proliferative activity in malignant cells and tissues. Data with respect to expression of PCNA in leukemia and in some solid tumors will be reviewed.

Original language	English (US)
Pages (from-to)	459-468
Number of pages	10
Journal	Leukemia and Lymphoma
Volume	6
Issue number	6
DOIs	https://doi.org/10.3109/10428199209053584
State	Published - 1992
Externally published	Yes

Keywords

Nuclear antigen cancer
PCNA
Proliferating cell nuclear antigen

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.3109/10428199209053584

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title = "Proliferating cell nuclear antigen: A new marker of proliferation in cancer",

abstract = "Proliferating cell nuclear antigen (PCNA) is the auxiliary protein of DNA polymerase δ It is induced in late G1 and S phases following mitotic stimulation of resting cells and is required for efficient DNA synthesis and cell cycle progression. Its expression in normal and malignant proliferating cells is related to proliferative activity. Because of the potential for substantial variability between proliferating cell populations with respect to the proportions of cells in G0 or G1, assays of PCNA can complement DNA analysis for assessment of proliferative activity in malignant cells and tissues. Data with respect to expression of PCNA in leukemia and in some solid tumors will be reviewed.",

keywords = "Nuclear antigen cancer, PCNA, Proliferating cell nuclear antigen",

author = "Keim, {David R.} and Hanash, {Sam M.}",

year = "1992",

doi = "10.3109/10428199209053584",

language = "English (US)",

volume = "6",

pages = "459--468",

journal = "Leukemia and Lymphoma",

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T2 - A new marker of proliferation in cancer

AU - Keim, David R.

AU - Hanash, Sam M.

PY - 1992

Y1 - 1992

N2 - Proliferating cell nuclear antigen (PCNA) is the auxiliary protein of DNA polymerase δ It is induced in late G1 and S phases following mitotic stimulation of resting cells and is required for efficient DNA synthesis and cell cycle progression. Its expression in normal and malignant proliferating cells is related to proliferative activity. Because of the potential for substantial variability between proliferating cell populations with respect to the proportions of cells in G0 or G1, assays of PCNA can complement DNA analysis for assessment of proliferative activity in malignant cells and tissues. Data with respect to expression of PCNA in leukemia and in some solid tumors will be reviewed.

AB - Proliferating cell nuclear antigen (PCNA) is the auxiliary protein of DNA polymerase δ It is induced in late G1 and S phases following mitotic stimulation of resting cells and is required for efficient DNA synthesis and cell cycle progression. Its expression in normal and malignant proliferating cells is related to proliferative activity. Because of the potential for substantial variability between proliferating cell populations with respect to the proportions of cells in G0 or G1, assays of PCNA can complement DNA analysis for assessment of proliferative activity in malignant cells and tissues. Data with respect to expression of PCNA in leukemia and in some solid tumors will be reviewed.

KW - Nuclear antigen cancer

KW - PCNA

KW - Proliferating cell nuclear antigen

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Proliferating cell nuclear antigen: A new marker of proliferation in cancer

Abstract

Keywords

ASJC Scopus subject areas

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