Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70

Wei Zhang; Johannes Drach; Michael Andreeff; Albert Deisseroth

doi:10.1016/0006-291X(92)90544-U

Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70

Wei Zhang, Johannes Drach, Michael Andreeff, Albert Deisseroth

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Abstract

In this study, we have examined the synthesis of heat shock protein (HSP70) in leukemia cells from acute myelogenous leukemia (AML) patients and in mononuclear cells from normal individuals, before and after growth factor stimulation. We have shown that the HSP70 protein was expressed in these cells in the absence of temperature elevation. Stimulation of proliferation of AML cells by the growth factors interleukin-3 and granulocyte-macrophage colony-stimulating factor and stimulation of normal lymphocytes by phytohemagglutinin (PHA) resulted in decreased synthesis of HSP70, suggesting that high levels of HSP70 are associated with cellular differentiation.

Original language	English (US)
Pages (from-to)	733-738
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	183
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(92)90544-U
State	Published - Mar 16 1992

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70",

abstract = "In this study, we have examined the synthesis of heat shock protein (HSP70) in leukemia cells from acute myelogenous leukemia (AML) patients and in mononuclear cells from normal individuals, before and after growth factor stimulation. We have shown that the HSP70 protein was expressed in these cells in the absence of temperature elevation. Stimulation of proliferation of AML cells by the growth factors interleukin-3 and granulocyte-macrophage colony-stimulating factor and stimulation of normal lymphocytes by phytohemagglutinin (PHA) resulted in decreased synthesis of HSP70, suggesting that high levels of HSP70 are associated with cellular differentiation.",

author = "Wei Zhang and Johannes Drach and Michael Andreeff and Albert Deisseroth",

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AU - Zhang, Wei

AU - Drach, Johannes

AU - Andreeff, Michael

AU - Deisseroth, Albert

PY - 1992/3/16

Y1 - 1992/3/16

N2 - In this study, we have examined the synthesis of heat shock protein (HSP70) in leukemia cells from acute myelogenous leukemia (AML) patients and in mononuclear cells from normal individuals, before and after growth factor stimulation. We have shown that the HSP70 protein was expressed in these cells in the absence of temperature elevation. Stimulation of proliferation of AML cells by the growth factors interleukin-3 and granulocyte-macrophage colony-stimulating factor and stimulation of normal lymphocytes by phytohemagglutinin (PHA) resulted in decreased synthesis of HSP70, suggesting that high levels of HSP70 are associated with cellular differentiation.

AB - In this study, we have examined the synthesis of heat shock protein (HSP70) in leukemia cells from acute myelogenous leukemia (AML) patients and in mononuclear cells from normal individuals, before and after growth factor stimulation. We have shown that the HSP70 protein was expressed in these cells in the absence of temperature elevation. Stimulation of proliferation of AML cells by the growth factors interleukin-3 and granulocyte-macrophage colony-stimulating factor and stimulation of normal lymphocytes by phytohemagglutinin (PHA) resulted in decreased synthesis of HSP70, suggesting that high levels of HSP70 are associated with cellular differentiation.

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Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70

Abstract

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