Proliferative verrucous leukoplakia: Recognition and differentiation from conventional leukoplakia and mimics

Ann M. Gillenwater; Nadarajah Vigneswaran; Hanadi Fatani; Pierre Saintigny; Adel K. El-Naggar

doi:10.1002/hed.23505

Proliferative verrucous leukoplakia: Recognition and differentiation from conventional leukoplakia and mimics

Ann M. Gillenwater, Nadarajah Vigneswaran, Hanadi Fatani, Pierre Saintigny, Adel K. El-Naggar

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

The majority of conventional leukoplakia remains constant and only a subset progress to high-grade dysplasia or invasive carcinoma. A less recognized form known as proliferative verrucous leukoplakia (PVL) represents a unique progressive and elusive variant. Identifying patients with this form can only be achieved through the keen clinical observation of the temporal gross and histologic progression in individual patients with squamous cell carcinoma. The difficulty in the early diagnosis of PVL stems from the overlapping clinical and pathologic features with conventional multifocal leukoplakia with dysplasia. We present the current view on the clinicopathologic and biological characteristics of PVL and discuss their diagnosis, differential diagnosis, and management.

Original language	English (US)
Pages (from-to)	1662-1668
Number of pages	7
Journal	Head and Neck
Volume	36
Issue number	11
DOIs	https://doi.org/10.1002/hed.23505
State	Published - Nov 1 2014

Keywords

lichen planus
oral leukoplakia
squamous dysplasia
squamous tumorigenesis
verrucous hyperplasia

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23505

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title = "Proliferative verrucous leukoplakia: Recognition and differentiation from conventional leukoplakia and mimics",

abstract = "The majority of conventional leukoplakia remains constant and only a subset progress to high-grade dysplasia or invasive carcinoma. A less recognized form known as proliferative verrucous leukoplakia (PVL) represents a unique progressive and elusive variant. Identifying patients with this form can only be achieved through the keen clinical observation of the temporal gross and histologic progression in individual patients with squamous cell carcinoma. The difficulty in the early diagnosis of PVL stems from the overlapping clinical and pathologic features with conventional multifocal leukoplakia with dysplasia. We present the current view on the clinicopathologic and biological characteristics of PVL and discuss their diagnosis, differential diagnosis, and management.",

keywords = "lichen planus, oral leukoplakia, squamous dysplasia, squamous tumorigenesis, verrucous hyperplasia",

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T1 - Proliferative verrucous leukoplakia

T2 - Recognition and differentiation from conventional leukoplakia and mimics

AU - Gillenwater, Ann M.

AU - Vigneswaran, Nadarajah

AU - Fatani, Hanadi

AU - Saintigny, Pierre

AU - El-Naggar, Adel K.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The majority of conventional leukoplakia remains constant and only a subset progress to high-grade dysplasia or invasive carcinoma. A less recognized form known as proliferative verrucous leukoplakia (PVL) represents a unique progressive and elusive variant. Identifying patients with this form can only be achieved through the keen clinical observation of the temporal gross and histologic progression in individual patients with squamous cell carcinoma. The difficulty in the early diagnosis of PVL stems from the overlapping clinical and pathologic features with conventional multifocal leukoplakia with dysplasia. We present the current view on the clinicopathologic and biological characteristics of PVL and discuss their diagnosis, differential diagnosis, and management.

AB - The majority of conventional leukoplakia remains constant and only a subset progress to high-grade dysplasia or invasive carcinoma. A less recognized form known as proliferative verrucous leukoplakia (PVL) represents a unique progressive and elusive variant. Identifying patients with this form can only be achieved through the keen clinical observation of the temporal gross and histologic progression in individual patients with squamous cell carcinoma. The difficulty in the early diagnosis of PVL stems from the overlapping clinical and pathologic features with conventional multifocal leukoplakia with dysplasia. We present the current view on the clinicopathologic and biological characteristics of PVL and discuss their diagnosis, differential diagnosis, and management.

KW - lichen planus

KW - oral leukoplakia

KW - squamous dysplasia

KW - squamous tumorigenesis

KW - verrucous hyperplasia

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Proliferative verrucous leukoplakia: Recognition and differentiation from conventional leukoplakia and mimics

Abstract

Keywords

ASJC Scopus subject areas

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