Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium

John Mascarenhas; Mark L. Heaney; Vesna Najfeld; Elizabeth Hexner; Omar Abdel-Wahab; Raajit Rampal; Farhad Ravandi; Bruce Petersen; Gail Roboz; Eric Feldman; Nikolai Podoltsev; Dan Douer; Ross Levine; Martin Tallman; Ronald Hoffman

doi:10.1016/j.leukres.2012.08.013

Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium

John Mascarenhas, Mark L. Heaney, Vesna Najfeld, Elizabeth Hexner, Omar Abdel-Wahab, Raajit Rampal, Farhad Ravandi, Bruce Petersen, Gail Roboz, Eric Feldman, Nikolai Podoltsev, Dan Douer, Ross Levine, Martin Tallman, Ronald Hoffman

Leukemia

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Leukemic transformation (LT) of a myeloproliferative neoplasm (MPN) is associated with a dismal prognosis and no medical therapies have shown a survival improvement in patients with MPN in blast phase (MPN-BP). Effective therapies for the treatment of MPN-BP are a serious unmet need. Consensus response criteria do not exist for the treatment of patients with MPN-BP and this is necessary for the uniformed reporting of treatment response in clinical trials. We have identified relevant MPN and MPN-BP features in order to define treatment response categories that reflect hematological, clinical, pathological, cytogenetic and molecular changes after therapeutic intervention. We plan to validate these proposed response criteria within multi-centered clinical trials.

Original language	English (US)
Pages (from-to)	1500-1504
Number of pages	5
Journal	Leukemia Research
Volume	36
Issue number	12
DOIs	https://doi.org/10.1016/j.leukres.2012.08.013
State	Published - Dec 2012

Keywords

Acute myeloid leukemia
Blast phase
Clinical trial
Myeloproliferative neoplasm
Response criteria

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Mascarenhas, J., Heaney, M. L., Najfeld, V., Hexner, E., Abdel-Wahab, O., Rampal, R., Ravandi, F., Petersen, B., Roboz, G., Feldman, E., Podoltsev, N., Douer, D., Levine, R., Tallman, M., & Hoffman, R. (2012). Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium. Leukemia Research, 36(12), 1500-1504. https://doi.org/10.1016/j.leukres.2012.08.013

Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium. / Mascarenhas, John; Heaney, Mark L.; Najfeld, Vesna et al.
In: Leukemia Research, Vol. 36, No. 12, 12.2012, p. 1500-1504.

Research output: Contribution to journal › Article › peer-review

Mascarenhas, J, Heaney, ML, Najfeld, V, Hexner, E, Abdel-Wahab, O, Rampal, R, Ravandi, F, Petersen, B, Roboz, G, Feldman, E, Podoltsev, N, Douer, D, Levine, R, Tallman, M & Hoffman, R 2012, 'Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium', Leukemia Research, vol. 36, no. 12, pp. 1500-1504. https://doi.org/10.1016/j.leukres.2012.08.013

Mascarenhas J, Heaney ML, Najfeld V, Hexner E, Abdel-Wahab O, Rampal R et al. Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium. Leukemia Research. 2012 Dec;36(12):1500-1504. doi: 10.1016/j.leukres.2012.08.013

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abstract = "Leukemic transformation (LT) of a myeloproliferative neoplasm (MPN) is associated with a dismal prognosis and no medical therapies have shown a survival improvement in patients with MPN in blast phase (MPN-BP). Effective therapies for the treatment of MPN-BP are a serious unmet need. Consensus response criteria do not exist for the treatment of patients with MPN-BP and this is necessary for the uniformed reporting of treatment response in clinical trials. We have identified relevant MPN and MPN-BP features in order to define treatment response categories that reflect hematological, clinical, pathological, cytogenetic and molecular changes after therapeutic intervention. We plan to validate these proposed response criteria within multi-centered clinical trials.",

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AU - Tallman, Martin

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Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium

Abstract

Keywords

ASJC Scopus subject areas

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