Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia

Richard A. Schwarz; Wen Gao; Vanda M.T. Stepanek; Tao T. Le; Vijayashree S. Bhattar; Michelle D. Williams; Jessica K. Wu; Nadarajah Vigneswaran; Karen Adler-Storthz; Ann M. Gillenwater; Rebecca Richards-Kortum

doi:10.1364/BOE.2.000089

Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia

Richard A. Schwarz, Wen Gao, Vanda M.T. Stepanek, Tao T. Le, Vijayashree S. Bhattar, Michelle D. Williams, Jessica K. Wu, Nadarajah Vigneswaran, Karen Adler-Storthz, Ann M. Gillenwater, Rebecca Richards-Kortum

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83.

Original language	English (US)
Pages (from-to)	89-99
Number of pages	11
Journal	Biomedical Optics Express
Volume	2
Issue number	1
DOIs	https://doi.org/10.1364/BOE.2.000089
State	Published - Jan 1 2011

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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Schwarz, R. A., Gao, W., Stepanek, V. M. T., Le, T. T., Bhattar, V. S., Williams, M. D., Wu, J. K., Vigneswaran, N., Adler-Storthz, K., Gillenwater, A. M., & Richards-Kortum, R. (2011). Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia. Biomedical Optics Express, 2(1), 89-99. https://doi.org/10.1364/BOE.2.000089

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abstract = "A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83.",

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AU - Vigneswaran, Nadarajah

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AU - Gillenwater, Ann M.

AU - Richards-Kortum, Rebecca

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AB - A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83.

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Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia

Abstract

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