TY - JOUR
T1 - Proteasomes beyond proteolysis
T2 - Roles in heterochromatin maintenance
AU - Bartholomew, Blaine
N1 - Publisher Copyright:
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2017/10/13
Y1 - 2017/10/13
N2 - In addition to its proteolytic roles, the 26S proteasome is involved in regulating transcription and in promoting sites of active chromatin. In this report, Seo et al. provide evidence that the non-proteolytic 19S subunit of the 26S proteasome also regulates the spreading of inactive chromatin referred to as heterochromatin, suggesting further non-canonical roles of the proteasome in gene expression.
AB - In addition to its proteolytic roles, the 26S proteasome is involved in regulating transcription and in promoting sites of active chromatin. In this report, Seo et al. provide evidence that the non-proteolytic 19S subunit of the 26S proteasome also regulates the spreading of inactive chromatin referred to as heterochromatin, suggesting further non-canonical roles of the proteasome in gene expression.
UR - http://www.scopus.com/inward/record.url?scp=85031306658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031306658&partnerID=8YFLogxK
U2 - 10.1074/jbc.H117.790824
DO - 10.1074/jbc.H117.790824
M3 - Review article
C2 - 29030538
AN - SCOPUS:85031306658
SN - 0021-9258
VL - 292
SP - 17156
EP - 17157
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 41
ER -